Rice protein improves adiposity, body weight and reduces lipids level in rats through modification of triglyceride metabolism

Lipids in Health and Disease

Hong-Kun Yang⁴  Qiao-Hong Liu³  Hua Zhang³  Tong Xu¹  Qiong Wu²  Jie Lv²  Jia-Hou Chen⁴  Lin Yang³ 

[1] Heilongjiang Provincial Hospital, Harbin 150036, China;School of Life Science and Biotechnology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150001, China;Department of Food Science, School of Food Science and Engineering, Harbin Institute of Technology, 73 Huanghe Road, Harbin 150090, China;Heilongjiang Provincial Environmental Monitoring Central Station, Harbin 150056, China

关键词: Rats;    Digestibility;    Lipolysis;    Lipogenesis;    Triglyceride;    Rice protein;   

Others  :  1160357
DOI  :  10.1186/1476-511X-11-24

 received in 2012-01-01, accepted in 2012-02-13,  发布年份 2012

【 摘 要 】

Background

To elucidate whether rice protein can possess a vital function in improving lipids level and adiposity, the effects of rice proteins extracted by alkaline (RP-A) and α-amylase (RP-E) on triglyceride metabolism were investigated in 7-week-old male Wistar rats fed cholesterol-enriched diets for 2 weeks, as compared with casein (CAS).

Results

Compared with CAS, plasma concentrations of glucose and lipids were significantly reduced by RP-feeding (P < 0.05), as well as hepatic accumulation of lipids (P < 0.05). RP-A and RP-E significantly depressed the hepatic activities of fatty acid synthase (FAS), glucose 6-phosphate dehydrogenase (G6PD) and malate dehydrogenase (MDH) (P < 0.05), whereas the activities of lipoprotein lipase (PL) and hepatic lipase (HL) were significantly stimulated (P < 0.05), as compared to CAS. Neither lipids level nor activities of enzymes were different between RP-A and RP-E (P > 0.05). There was a significant positive correlation between protein digestibility and deposit fat (r = 0.8567, P < 0.05), as well as the plasma TG concentration (r = 0.8627, P < 0.05).

Conclusions

The present study demonstrates that rice protein can modify triglyceride metabolism, leading to an improvement of body weight and adiposity. Results suggest that the triglyceride-lowering action as well as the potential of anti-adiposity induced by rice protein is attributed to upregulation of lipolysis and downregulation of lipogenesis, and the lower digestibility of rice protein may be the main modulator responsible for the lipid-lowering action.

【 授权许可】

   
2012 Yang et al; licensee BioMed Central Ltd.

【 图 表 】

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