The clinical use of biomarkers as prognostic factors in Ewing sarcoma

Clinical Sarcoma Research

Andrew B Hassan²  Pancras CW Hogendoorn¹  Annmeik M van Maldegem³ 

[1] Department of Pathology, Leiden University Medical Centre, PO Box 9600, 2600 RC Leiden, The Netherlands;Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK;Department of Oncology University of Oxford, Oxford, OX3 7LJ, UK

关键词: biomarkers;    prognostic;    Ewing sarcoma;   

Others  :  862980
DOI  :  10.1186/2045-3329-2-7

 received in 2011-06-25, accepted in 2012-02-08,  发布年份 2012

【 摘 要 】

Ewing Sarcoma is the second most common primary bone sarcoma with 900 new diagnoses per year in Europe (EU27). It has a poor survival rate in the face of metastatic disease, with no more than 10% survival of the 35% who develop recurrence. Despite the remaining majority having localised disease, approximately 30% still relapse and die despite salvage therapies. Prognostic factors may identify patients at higher risk that might require differential therapeutic interventions. Aside from phenotypic features, quantitative biomarkers based on biological measurements may help identify tumours that are more aggressive. We audited the research which has been done to identify prognostic biomarkers for Ewing sarcoma in the past 15 years. We identified 86 articles were identified using defined search criteria. A total of 11,625 patients were reported, although this number reflects reanalysis of several cohorts. For phenotypic markers, independent reports suggest that tumour size > 8 cm and the presence of metastasis appeared strong predictors of negative outcome. Good histological response (necrosis > 90%) after treatment appeared a significant predictor for a positive outcome. However, data proposing biological biomarkers for practical clinical use remain un-validated with only one secondary report published. Our recommendation is that we can stratify patients according to their stage and using the phenotypic features of metastases, tumour size and histological response. For biological biomarkers, we suggest a number of validating studies including markers for 9p21 locus, heat shock proteins, telomerase related markers, interleukins, tumour necrosis factors, VEGF pathway, lymphocyte count, and a number of other markers including Ki-67.

【 授权许可】

   
2012 van Maldegem et al; licensee BioMed Central Ltd.

【 图 表 】

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