Association between alkaline phosphatase and hypertension in a rural Japanese population: The Nagasaki Islands study

Journal of Physiological Anthropology

Takahiro Maeda¹  Yosuke Kusano⁵  Kiyoshi Aoyagi⁶  Noboru Takamura⁴  Hironori Yamasaki³  Koichiro Kadota²  Takaharu Sekita¹  Mio Nakazato¹  Yuji Shimizu¹ 

[1] Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan;Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan;Center for Health and Community Medicine, Nagasaki University, Nagasaki, Japan;Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan;Department of Community Development, Nagasaki Wesleyan University, Nagasaki, Japan;Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

关键词: Cross-sectional Study;    Risk;    Hypertension;    Drinking Status;    Alkaline Phosphatase;   

Others  :  861680
DOI  :  10.1186/1880-6805-32-10

 received in 2013-02-04, accepted in 2013-05-24,  发布年份 2013

【 摘 要 】

Background

Although serum alkaline phosphatase (ALP) levels have been associated with hypertension, and ALP is known as an enzyme affected by alcohol consumption, no study has been published on the associations between ALP and the risk of hypertension in relation to drinking status.

Methods

We conducted a cross-sectional study of 2,681 participants (837 men and 1,846 women) aged 30 to 89 years undergoing a general health check-up to investigate the associations between ALP and hypertension in relation to drinking status.

Results

Of the 2,681 participants, 1,549 (514 men and 1,035 women) were diagnosed with hypertension. A sex difference was observed for the relationship between ALP and hypertension. While no significant association was observed for men, the association was significantly positive for women. The multivariable adjusted odds ratio and 95% coincidence interval (CI) of hypertension per increment of 1-log ALP were 0.95 (95% CI: 0.56 to 1.59) for men and 1.57 (95% CI: 1.07 to 2.33) for women. When this analysis was restricted to nondrinkers, a significantly elevated risk of hypertension was observed for men and remained significant for women; that is, 3.32 (95% CI: 1.38 to 8.02) for men and 1.68 (95% CI: 1.11 to 2.55) for women.

Conclusion

ALP is associated with hypertension for both male and female nondrinkers, but not for drinkers. For analyses of associations between ALP and blood pressure, alcohol consumption should thus be considered a potential confounder.

【 授权许可】

   
2013 Yuji et al.; licensee BioMed Central Ltd.

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