Association of insulin resistance and coronary artery remodeling: an intravascular ultrasound study

Cardiovascular Diabetology

Seung-Yun Cho²  Dong-Hun Cha²  Sang-Wook Lim²  In Jai Kim²  Seung Min Yoo¹  Jung-Hoon Sung²  Woo-In Yang²  Kyung Ho Kim²  Yeong Min Lim²  Jae-Youn Moon²  Sang-Hoon Kim² 

[1] Department of Diagnostic Radiology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea;Department of Cardiology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea

关键词: Intravascular ultrasound;    Coronary artery remodeling;    Metabolic syndrome;    Insulin resistance;   

Others  :  1216835
DOI  :  10.1186/s12933-015-0238-8

 received in 2015-03-16, accepted in 2015-06-02,  发布年份 2015

【 摘 要 】

Background

There are few studies that investigated the correlation between insulin resistance (IR) and the coronary artery remodeling. The aim of the study is to investigate the association of IR measured by homeostasis model assessment of insulin resistance (HOMA-IR) and coronary artery remodeling evaluated by intravascular ultrasound (IVUS).

Methods

A total of 298 consecutive patients who received percutaneous coronary interventions under IVUS guidance were retrospectively enrolled. The value of HOMA-IR more than 2.5 was considered as IR positive. Metabolic syndrome was classified according to NCEP ATP III guidelines. The remodeling index was defined as the ratio of the external elastic membrane (EEM) area at the lesion site to the EEM area at the proximal reference site.

Results

A total of 369 lesions were analyzed (161 lesions in HOMA-IR positive and 208 lesions in HOMA-IR negative). Remodeling index was significantly higher in the HOMA-IR positive group compared with the negative group (HOMA-IR positive vs. negative: 1.074 ± 0.109 vs. 1.042 ± 0.131, p = 0.013). There was a significant positive correlation between remodeling index and HOMA-IR (p = 0.010). Analysis of HOMA-IR according to remodeling groups showed increasing tendency of HOMA-IR, and it was statistically significant (p = 0.045). Multivariate analysis revealed that only HOMA-IR was an independent predictor of remodeling index (r = 0.166, p = 0.018).

Conclusion

Increased IR estimated by HOMA-IR was significantly associated with a higher remodeling index and positive coronary artery remodeling.

【 授权许可】

   
2015 Kim et al.

【 图 表 】

Fig. 1.

Fig. 2.

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