Giant anal condyloma (giant condyloma acuminatum of anus) after allogeneic bone marrow transplantation associated with human papillomavirus: a case report

Journal of Medical Case Reports

Sang-Gon Park⁵  Min-Sung Kim³  Byung-Seok Choi¹  Gee-Bum Kim²  Jin-Soo Hyun⁴ 

[1] Department of Medicine, Graduate School of Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 501-717, Republic of Korea;Department of Medicine, Graduate School of Chosun University, Misigain Skin Clinic, 6th neopraza building 936 sau-dong, Gimpo, Gyeonggi, Republic of Korea;Department of Dermatology, Chosun University Hospital, 365 Pilmun-daero, Dong-gu, Gwangju 501-717, Republic of Korea;Department of Internal Medicine, Chosun University Hospital, 365 Pilmun-daero, Dong-gu, Gwangju 501-717, Republic of Korea;Department of Internal Medicine, Hemato-oncology, 365 Pilmun-daero, Dong-gu, Gwangju 501-717, Republic of Korea

关键词: Anus condyloma;    Allogenic bone marrow transplantation;    HPV;    Condyloma;   

Others  :  1180805
DOI  :  10.1186/1752-1947-9-9

 received in 2014-08-18, accepted in 2014-11-30,  发布年份 2015

【 摘 要 】

Introduction

Condyloma acuminatum are caused by human papillomavirus. Giant condyloma acuminatum is a locally invasive, destructive, and large sized mass. Risk factors for the development of giant condyloma acuminatum include an immunodeficient state, such as human immunodeficiency virus infection, post-organ transplantation, or post-allogeneic bone marrow transplantation. However, reports of giant condyloma after bone marrow transplantation are extremely rare (0.3 to 1.3%). The standard treatment for giant condyloma acuminatum is recommended as wide surgical resection due to its high rate of success and low rate of recurrence.

Case presentation

A 31-year-old Korean man presented to our hospital with anal discomfort for more than one month due to a protruding mass. He had a history of BCR-ABL-positive acute lymphoblastic leukemia and had undergone an allogenic stem cell transplantation. Gross findings revealed a large perianal cauliflower-like mass over 7cm in size with invasion of the anal orifice. He was diagnosed with giant anal condyloma occurring after an allogeneic bone marrow transplantation. However, we achieved successful treatment using a combination of topical podophyllin and cryotherapy and transanal surgical excision, followed by bleomycin irrigation.

Conclusions

We report an extremely rare case of giant condyloma acuminatum of anus due to human papillomavirus type six in a patient with acute lymphoblastic leukemia following an allogeneic bone marrow transplantation. The tumor was successfully treated with a combination of topical podophyllin and cryotherapy and transanal surgical excision, followed by bleomycin irrigation.

【 授权许可】

   
2015 Hyun et al.; licensee BioMed Central.

【 图 表 】

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