Effects of 60 minutes of hyperoxia followed by normoxia before coronary artery bypass grafting on the inflammatory response profile and myocardial injury

Journal of Negative Results in Biomedicine

Joel Starkopf³  Mihkel Zilmer²  Kersti Zilmer²  Arno Ruusalepp³  Peeter Tähepõld³  Inga Karu¹ 

[1] Department of Anaesthesiology and Intensive Care, University of Tartu, Puusepa 8, Tartu, Estonia;Institute of Biochemistry, Centre of Excellence for Translational Medicine, University of Tartu, Tartu, Estonia;Tartu University Hospital, Tartu, Estonia

关键词: Interferon gamma;    Tumor necrosis factor alfa;    Interleukin;    Cytokine;    Troponin T;    Hyperoxia;    Preconditioning;    Coronary artery bypass grafting;   

Others  :  815292
DOI  :  10.1186/1477-5751-11-14

 received in 2012-04-18, accepted in 2012-09-11,  发布年份 2012

【 摘 要 】

Background

Ischemic preconditioning induces tolerance against ischemia-reperfusion injury prior a sustained ischemic insult. In experimental studies, exposure to hyperoxia for a limited time before ischemia induces a low-grade systemic oxidative stress and evokes an (ischemic) preconditioning-like effect of the myocardium. We hypothesised that pre-treatment by hyperoxia favours enchanced myocardial protection described by decreased release of cTn T in the 1^st postoperative morning and reduces the release of inflammatory cytokines.

Methods

Forty patients with stable coronary artery disease underwent coronary artery bypass grafting with cardiopulmonary bypass. They were ventilated with 40 or >96% oxygen for 60 minutes followed by by 33 (18–59) min normoxia before cardioplegia.

Results

In the 1^st postoperative morning concentrations of cTnT did not differ between groups ((0.44 (0.26-0.55) ng/mL in control and 0.45 (0.37-0.71) ng/mL in hyperoxia group). Sixty minutes after declamping the aorta, ratios of IL-10/IL-6 (0.73 in controls and 1.47 in hyperoxia, p = 0.03) and IL-10/TNF-α (2.91 and 8.81, resp., p = 0.015) were significantly drifted towards anti-inflammatory, whereas interleukins 6, 8and TNF-α and interferon-γ showed marked postoperative rise, but no intergroup differences were found.

Conclusions

Pre-treatment by 60 minutes of hyperoxia did not reduce postoperative leak of cTn T in patients undergoing coronary artery bypass surgery. In the hyperoxia group higher release of anti-inflammatory IL-10 caused drifting of IL-10/IL-6 and IL-10/TNF-α towards anti-inflammatory.

【 授权许可】

   
2012 Karu et al.; licensee BioMed Central Ltd.

【 图 表 】

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