Salivary uric acid as a noninvasive biomarker of metabolic syndrome

Diabetology & Metabolic Syndrome

Kristie Grove Bridges⁴  Andrea M Nazar¹  Edward G Bridges⁴  Lance Ridpath³  Derek Rodeback⁴  Benmichael Idowu⁴  Aaron Henderson²  Izabela Biesiada⁴  Maria Soukup⁴ 

[1] Department of Clinical Sciences, West Virginia School of Osteopathic Medicine, Lewisburg, WV, USA;Current affiliation, Department of Internal Medicine, San Antonio Uniformed Services Health Education Consortium, San Antonio, TX, USA;Department of Assessment and Educational Development, West Virginia School of Osteopathic Medicine, Lewisburg, WV, USA;Department of Biomedical Sciences, West Virginia School of Osteopathic Medicine, 400 N Lee St, Lewisburg, WV, USA

关键词: Uric acid;    Metabolic syndrome;    Biomarker;    Saliva;   

Others  :  817356
DOI  :  10.1186/1758-5996-4-14

 received in 2012-02-14, accepted in 2012-04-19,  发布年份 2012

【 摘 要 】

Background

Elevated serum uric acid is associated with obesity, hypertension and metabolic syndrome. Because a linear relationship exists between serum and salivary uric acid (SUA) concentration, saliva testing may be a useful noninvasive approach for monitoring cardiometabolic risk. The goal of this pilot study was to determine if SUA is increased in patients with metabolic syndrome and to investigate correlations between SUA and individual cardiometabolic risk factors.

Findings

Volunteers between the ages of 18 and 65 without conditions known to affect serum uric acid levels were recruited. Height, weight, blood pressure and waist circumference were measured and a full lipid panel along with fasting blood glucose was obtained. Saliva samples were collected and uric acid levels were determined. 78 volunteers, 35% of whom had metabolic syndrome, completed the study. SUA was significantly elevated in patients with metabolic syndrome (p=.002). The incidence of metabolic syndrome in the 4^th quartile for SUA was 67% compared to 25% in quartiles1-3 combined. Significant correlations were seen between SUA and systolic blood pressure (r=.440, p=.000), diastolic blood pressure ( r=.304, p=.007), waist circumference (r=.332, p=.003), BMI ( r=.269, p=.018), fasting blood glucose ( r=.341, p=.002), triglycerides (r=.410, p=.000), HDL ( r=.237, p=.036) and the number of cardiometabolic risk factors present (r=0.257, p=.023).

Conclusions

These results suggest that SUA may be a useful biomarker for noninvasive monitoring of cardiometabolic risk. Larger studies are needed to validate this approach.

【 授权许可】

   
2012 Soukup et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1 .

Figure 2 .

【 参考文献 】

• [1]Gimno F: West Virginia Behavioral Risk Factor Survey Report. 2006. [http://www.wvdhhr.org/bph/HSC/Pubs/BRFSS/2006/default.htm webcite]
• [2]Kassi E, Pervanidou P, Kaltsas G, Chrousos G: Metabolic syndrome: definitions and controversies. BMC Med 2011, 9:48. BioMed Central Full Text
• [3]Deskins S, Harris CV, Bradlyn AS, Cottrell L, Coffman JW, Olexa J, Neal W: Preventive care in Appalachia: use of the theory of planned behavior to identify barriers to participation in cholesterol screenings among West Virginians. J Rural Health 2006, 22:367-374.
• [4]Mamali I, Roupas ND, Armeni AK, Theodoropoulou A, Markou KB, Georgopoulos NA: Measurement of salivary resistin, visfatin and adiponectin levels. Peptides 2012, 33:120-124.
• [5]Ouellet-Morin I, Danese A, Williams B, Arseneault L: Validation of a high-sensitivity assay for C-reactive protein in human saliva. Brain Behav Immun 2011, 25:640-646.
• [6]Dillon MC, Opris DC, Kopanczyk R, Lickliter J, Cornwell HN, Bridges EG, Nazar AM, Bridges KG: Detection of homocysteine and C-reactive protein in the saliva of healthy adults: comparison with blood levels. Biomark Insights 2010, 5:57-61.
• [7]Goll RD, Mookerjee BK: Correlation of biochemical parameters in serum and saliva in chronic azotemic patients and patients on chronic hemodialysis. J Dial 1978, 2:344-399.
• [8]Nunes LA, Brenzikofer R, Macedo DV: Reference intervals for saliva analytes collected by a standardized method in a physically active population. Clin Biochem 2011, 44:1440-1444.
• [9]Nakagawa T, Cirillo P, Sato W, Gersch M, Sautin Y, Roncal C, Mu W, Snchez-Lozada LG, Johnson RJ: The conundrum of hyperuricemia, metabolic syndrome, and renal disease. Intern Emerg Med 2008, 3:313-318.
• [10]Lippi G, Montagnana M, Franchini M, Favaloro EJ, Targher G: The paradoxical relationship between serum uric acid and cardiovascular disease. Clin Chim Acta 2008, 392:1-7.
• [11]Henderson AT, Fisher JF, Blair J, Shea C, Li TS, Bridges KG: Effects of rib raising on the autonomic nervous system: a pilot study using noninvasive biomarkers. J Am Osteopath Assoc 2010, 110:324-330.
• [12]Centers for Disease Control and Prevention: The Third National Center for Health Statistics: National Health and Nutrition Examination Survey (NHANES III 1988–94) reference manuals and reports. National Center for Health Statistics, Bethesda, MD; 1996.
• [13]Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC: Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009, 120:1640-1645.
• [14]Giannobile WV, McDevitt JT, Niedbala RS, Malamud D: Translational and clinical applications of salivary diagnostics. Adv Dent Res 2011, 23:375-380.
• [15]Rodrigues SL, Baldo MP, Capingana P, Magalhes P, Dantas EM, Molina MD, Salaroli LB, Morelato RL, Mill JG: Gender distribution of serum uric acid and cardiovascular risk factors: a population based study. Arq Bras Cardiol 2012, 98:13-21.
• [16]Yang T, Chu CH, Bai CH, You SL, Chou YC, Chou WY, Chien KL, Hwang LC, Su TC, Tseng CH, Sun CA: Uric acid level as a risk marker for metabolic syndrome: a Chinese cohort study. Atherosclerosis 2012, 220:525-531.
• [17]Chiou WK, Wang MH, Huang DH, Chiu HT, Lee YJ, Lin JD: The relationship between serum uric acid level and metabolic syndrome: differences by sex and age in Taiwanese. J Epidemiol 2010, 20:219-224.
• [18]Tremblay M, Loucif Y, Methot J, Brisson D, Gaudet D: Salivary pH as a marker of plasma adiponectin concentrations in women. Diabetol Metab Syndr 2012, 4:4. BioMed Central Full Text
• [19]Qvarnstrom M, Janket SJ, Jones JA, Jethwani K, Nuutinen P, Garcia RI, Baird AE, Van Dyke TE, Meurman JH: Association of salivary lysozyme and C-reactive protein with metabolic syndrome. J Clin Periodontol 2010, 37:805-811.