Endometrial stem cells in regenerative medicine

Journal of Biological Engineering

Alexander M Seifalian²  Alireza Shoae-Hassani¹  Aaron Tan³  Javad Verdi¹ 

[1] Applied Cell Sciences Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran;Royal Free London NHS Foundation Trust Hospital, London, UK;UCL Medical School, University College London (UCL), London, UK

关键词: Regenerative medicine;    Endometrium;    Endometrial regenerative cells;    Menstrual blood stem cells;    Endometrial stem cells;   

Others  :  1135884
DOI  :  10.1186/1754-1611-8-20

 received in 2014-04-05, accepted in 2014-06-30,  发布年份 2014

【 摘 要 】

First described in 2004, endometrial stem cells (EnSCs) are adult stem cells isolated from the endometrial tissue. EnSCs comprise of a population of epithelial stem cells, mesenchymal stem cells, and side population stem cells. When secreted in the menstrual blood, they are termed menstrual stem cells or endometrial regenerative cells. Mounting evidence suggests that EnSCs can be utilized in regenerative medicine. EnSCs can be used as immuno-modulatory agents to attenuate inflammation, are implicated in angiogenesis and vascularization during tissue regeneration, and can also be reprogrammed into induced pluripotent stem cells. Furthermore, EnSCs can be used in tissue engineering applications and there are several clinical trials currently in place to ascertain the therapeutic potential of EnSCs. This review highlights the progress made in EnSC research, describing their mesodermal, ectodermal, and endodermal potentials both in vitro and in vivo.

【 授权许可】

   
2014 Verdi et al.; licensee BioMed Central Ltd.

【 图 表 】

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