Persistent organic pollutants as risk factors for type 2 diabetes

Diabetology & Metabolic Syndrome

Eugene Sobngwi³  Edith-Pascale Mofo-Mato²  Barbara Tiedeu-Atogho²  Andre-Pascal Kengne¹  Elvis Ndonwi Ngwa² 

[1] Department of Medicine, University of Cape Town, Cape Town, South Africa;Laboratory of Molecular Medicine and Metabolism, Biotechnology Centre Nkolbisson, Biotechnology Centre Nkolbisson, Yaounde, Cameroon;National Obesity Center, Yaoundé Central Hospital and Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon

关键词: Insulin resistance;    Insulin secretion;    In utero exposure;    Persistent organic pollutants;    Type 2 diabetes;   

Others  :  1210941
DOI  :  10.1186/s13098-015-0031-6

 received in 2014-09-27, accepted in 2015-04-02,  发布年份 2015

【 摘 要 】

Type 2 diabetes mellitus (T2DM) is a major and fast growing public health problem. Although obesity is considered to be the main driver of the pandemic of T2DM, a possible contribution of some environmental contaminants, of which persistent organic pollutants (POPs) form a particular class, has been suggested. POPs are organic compounds that are resistant to environmental degradation through chemical, biological, and photolytic processes which enable them to persist in the environment, to be capable of long-range transport, bio accumulate in human and animal tissue, bio accumulate in food chains, and to have potential significant impacts on human health and the environment. Several epidemiological studies have reported an association between persistent organic pollutants and diabetes risk. These findings have been replicated in experimental studies both in human (in-vitro) and animals (in-vivo and in-vitro), and patho-physiological derangements through which these pollutants exercise their harmful effect on diabetes risk postulated. This review summarizes available studies, emphasises on limitations so as to enable subsequent studies to be centralized on possible pathways and bring out clearly the role of POPs on diabetes risk.

【 授权许可】

   
2015 Ngwa et al.; licensee BioMed Central.