Arsenic trioxide improves hematopoiesis in refractory severe aplastic anemia

Journal of Hematology & Oncology

Baijun Fang¹  Jian Zhou²  Yongping Song²  Ning Li² 

[1] Henan Institute of Haematology, Henan Tumor Hospital affiliated to Zhengzhou University, 127 Dongming Road, Zhengzhou, 450008, China;Henan Key Lab of Experimental Haematology, Henan Institute of Haematology, Henan Tumor Hospital affiliated to Zhengzhou University, Zhengzhou, China

关键词: Mesenchymal stem cells;    Adipocytes;    Arsenic trioxide;    Hematopoiesis;    Aplastic anemia;   

Others  :  822070
DOI  :  10.1186/1756-8722-5-61

 received in 2012-10-03, accepted in 2012-10-04,  发布年份 2012

【 摘 要 】

We investigated the efficacy of arsenic trioxide (ATO) in patients with refractory severe aplastic anemia (SAA). A total of 5 consecutive adults were enrolled. The patients received ATO at a dose of 0.15 mg/kg intravenously daily for 5 days every week for 8 weeks. If necessary, a second course was performed after an interval of one week. All patients achieved clinically significant responses to ATO. The overall complete response rate and overall response rate at 17 weeks were 60% (3/5) and 100%(5/5), respectively. So treatment with ATO may be a feasible approach in patients with refractory SAA.

【 授权许可】

   
2012 Li et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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