Evaluation of tumor response to cytokine-induced killer cells therapy in malignant solid tumors

Journal of Translational Medicine

Jing-Ting Jiang⁴  Chang-Ping Wu⁴  Binfeng Lu¹  Jun Wu³  Zhong-Hua Ning²  Xiao Zheng⁴  Mei Ji³  Xiao-Dong Li⁴ 

[1] Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, USA;Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China;Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China;Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China

关键词: Evaluation system;    Tumor response;    CIK cells therapy;   

Others  :  1148477
DOI  :  10.1186/s12967-014-0215-0

 received in 2014-06-23, accepted in 2014-07-21,  发布年份 2014

【 摘 要 】

CIK cells therapy has been evaluated as an adoptive cell immunotherapy for cancer patients, but there still have not been any standardized systems for evaluating the antitumor efficacy yet. The WHO and RECIST criteria have already been established for a few years but not sufficient to fully characterize the activity of immunotherapy. Based on these two criteria, the irRC was proposed for evaluating the efficacy of immunotherapy. A variety of bioassays for immune monitoring including the specific and non-specific methods, have been established. We recommend detect levels of various immunocytes, immune molecules and soluble molecules to find the correlations among them and clinicopathological characteristics to establish criteria for immunological classification. We also recommend a paradigm shift for the oncologists in the evaluation of immune therapies to ensure assessment of activity based on clinically relevant criteria and time points.

【 授权许可】

   
2014 Li et al.; licensee BioMed Central Ltd.

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