Cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke

Journal of Neuroinflammation

Urszula Demkow¹  Marek Radkowski³  Pawel J Winklewski² 

[1] Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland;Institute of Human Physiology, Medical University of Gdansk, Tuwima Street 15, Gdansk, 80-210, Poland;Department of Immunopathology of Infectious and Parasitic Diseases, Medical University of Warsaw, Warsaw, Poland

关键词: Pneumonia;    Lung injury;    Sympathetic nervous system;    Immune response;    Brain injury;    Stroke;   

Others  :  1149692
DOI  :  10.1186/s12974-014-0213-4

 received in 2014-09-02, accepted in 2014-12-02,  发布年份 2014

【 摘 要 】

The immune system response and inflammation play a key role in brain injury during and after a stroke. The acute immune response is responsible for secondary brain tissue damage immediately after the stroke, followed by immunosuppression due to sympathetic nervous system activation. The latter increases risk of infection complications, such as pneumonia. The pneumonia-related inflammatory state can release a bystander autoimmune response against central nervous system antigens, thereby initiating a vicious circle. The aim of this review is to summarize the relationship between ischemic stroke, sympathetic nervous system activation and pulmonary infection.

【 授权许可】

   
2014 Winklewski et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

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