Prevalence and prevalence trends of transfusion transmissible infections among blood donors at four chinese regional blood centers between 2000 and 2010

Journal of Translational Medicine

Wuping Li¹  Hongxiang Zhao²  Changzhou Lin⁶  Yan Luan⁴  Yonglin Yang⁵  Jianmin Ge²  Yongshui Fu⁶  Yudong Dai⁵  Jianping Li⁴  Miao He⁷  Huimin Yin³  Xiaopu Xiao⁷  Changqing Li⁷ 

[1] Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;Yan Cheng Blood Center, Nanjing, China;Department of Biology, Faculty of Pure and Applied Science, Acadia University, Wolfville, Canada;Liao Ning Blood Center, Shenyang, China;Nan Jing Blood Center, Nanjing, China;Guang Zhou Blood Center, Guangdong, China;Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Hua Cai Road 26 Hao, Dong San Huan Road Er Duan, Chengdu, Sichuang, 610052, China

关键词: Syphilis;    HCV;    HBV;    HIV;    Prevalence;    Transfusion;   

Others  :  1205905
DOI  :  10.1186/1479-5876-10-176

 received in 2012-05-14, accepted in 2012-08-16,  发布年份 2012

【 摘 要 】

Background

In China, high prevalence of HBV and HCV parallels with the growing epidemic of syphilis and HIV in the general population poses a great threat to blood safety. This study investigated the prevalence of serologic markers for transfusion transmissible infections (TTIs) among four Chinese blood centers.

Methods

We examined whole blood donations collected from January 2000 through December 2010 at four Chinese blood centers. Post-donation testing of TTIs (HIV, HBV, HCV and syphilis) were conducted using two different enzyme-linked immunosorbent assay kits for each seromarker. The prevalence of serologic markers for TTIs (%) was calculated and additional analysis was conducted to examine donor characteristics associated with positive TTIs serology.

Results

Of the 4,366,283 donations, 60% were from first-time donors and 40% were from repeated donors. The overall prevalence of HIV, HBsAg, HCV and syphilis was 0.08%, 0.86%, 0.51% and 0.47%, respectively. The prevalence profile of TTIs varied among different blood centers and appeared at relatively high levels. Overall, the prevalence of HBsAg and HCV demonstrated a decline trend among four blood centers, while the prevalence of HIV and syphilis displayed three different trends: constantly steady, continually increasing and declining among different centers.

Conclusions

This study reflects the risk of TTIs has been greatly reduced in China, but blood transfusion remains an ongoing risk factor for the spread of blood-borne infections, and further work and improvements are needed to strengthen both safety and availability of blood in China.

【 授权许可】

   
2012 Li et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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