Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation

Journal of Neuroinflammation

Gunnar Schulte¹  Ernest Arenas²  Eva Lindgren¹  Juan Carlos Villaescusa²  Javier Becerril-Ortega¹  Michaela Brita Christina Kilander¹  Jacomijn Petronella Dijksterhuis¹  Carina Halleskog¹ 

[1]Dept. Physiology & Pharmacology, Sec. Receptor Biology & Signaling, Karolinska Institutet, Nanna Svartz väg 2, Stockholm, S-17177, Sweden

[2]Dept. Medical Biochemistry & Biophysics, Sec. Molecular Neurobiology, Karolinska Institutet, Retzius väg 8, Stockholm, S-17177, Sweden

关键词: Neuroinflammation;    Microglia;    Cyclic AMP;    Non-canonical WNT signaling;    MAPK;    Heterotrimeric G proteins;    Frizzled;   

Others  :  1212569
DOI  :  10.1186/1742-2094-9-111

 received in 2011-12-12, accepted in 2012-04-30,  发布年份 2012

【 授权许可】

   
2012 Halleskog et al.; licensee BioMed Central Ltd.

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