Defining a new vision for the retinoblastoma gene: report from the 3rd International Rb Meeting

Cell Division

Julien Sage¹  Seth M Rubin² 

[1] Departments of Pediatrics and Genetics, Stanford University, Stanford, CA 94305, USA;Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA

关键词: Cyclin;    CDK;    E2F;    p130;    p107;    Rb;    Retinoblastoma;   

Others  :  790406
DOI  :  10.1186/1747-1028-8-13

 received in 2013-11-19, accepted in 2013-11-20,  发布年份 2013

【 摘 要 】

The retinoblastoma tumor suppressor (Rb) pathway is mutated in most, if not all human tumors. In the G0/G1 phase, Rb and its family members p107 and p130 inhibit the E2F family of transcription factors. In response to mitogenic signals, Cyclin-dependent kinases (CDKs) phosphorylate Rb family members, which results in the disruption of complexes between Rb and E2F family members and in the transcription of genes essential for S phase progression. Beyond this role in early cell cycle decisions, Rb family members regulate DNA replication and mitosis, chromatin structure, metabolism, cellular differentiation, and cell death. While the RB pathway has been extensively studied in the past three decades, new investigations continue to provide novel insights into basic mechanisms of cancer development and, beyond cancer, help better understand fundamental cellular processes, from plants to mammals. This meeting report summarizes research presented at the recently held 3rd International Rb Meeting.

【 授权许可】

   
2013 Rubin and sage; licensee BioMed Central Ltd.

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