Intestinal dysbacteriosis induces changes of T lymphocyte subpopulations in Peyer’s patches of mice and orients the immune response towards humoral immunity

Gut Pathogens

Li Tang¹  Shu Wen¹  Chuanzhou Gao²  Yinhui Liu¹  Ming Li¹  Fei Gao¹ 

[1] Department of Microecology, Dalian Medical University, No.9 Western Section, Lvshun South Street, Lvshunkou District, Dalian, 116044, China;Central Laboratory of Dalian Medical University, Dalian Medical University, No.9 Western Section, Lvshun South Street, Lvshunkou District, Dalian, 116044, China

关键词: Cytokines;    T lymphocytes;    Immune response;    Peyer’s patches;    Intestinal dysbacteriosis;   

Others  :  821819
DOI  :  10.1186/1757-4749-4-19

 received in 2012-10-09, accepted in 2012-12-06,  发布年份 2012

【 摘 要 】

The large numbers of human intestinal microorganisms have a highly co-evolved relationship with the immune system. Dysbacteriosis of intestinal microbiota induces alterations of immune responses, and is closely related to disease development. Peyer’s patches are immune sensors in intestine which exert essential functions during development of inflammatory disease. However, interactions between commensal bacteria and PPs have been poorly characterized. In this study, changes of lymphocyte subpopulations and production of cytokines in PPs of mice with intestinal dysbacteriosis were investigated. The ceftriaxone-induced dysbacteriosis caused a notable change in populations of T lymphocytes, their subpopulations in PPs and expressions of various cytokines. Our results suggest intestinal dysbacteriosis in mice reduces immune tolerance in PPs and orients immune response towards humoral immunity.

【 授权许可】

   
2012 Gao et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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