The prevalence of the metabolically healthy obese phenotype in an aging population and its association with subclinical cardiovascular disease: The Brazilian study on healthy aging

Diabetology & Metabolic Syndrome

Andrei Sposito⁵  Khurram Nasir²  Hamid Feiz⁴  Raul D Santos⁷  Roger Blumenthal¹  Arthur Agatston⁶  Michael Blaha¹  Wladimir Freitas³  Ehimen Aneni⁶  Sameer Shaharyar⁴  Lara Roberson⁶ 

[1] Johns Hopkins Hospital Ciccarone Preventive Cardiology Center, Baltimore, MD, USA;Department of Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA;Cardiology Department, State University of Campinas School of Medicine Campinas, Sao Paulo, Brazil;Aventura Hospital & Medical Center, Aventura, FL, USA;Cardiology Division, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Cidade Universitária, Campinas, SP, 13084-971, Brazil;Center for Prevention and Wellness Research, Baptist Health Medical Group, Miami Beach, FL, USA;Lipid Clinic- Heart Institute (InCor), University of São Paulo Medical School Hospital, Sao Paulo, Brazil

关键词: Subclinical CVD;    Metabolic Syndrome;    Aging;    Obesity;   

Others  :  1114899
DOI  :  10.1186/1758-5996-6-121

 received in 2014-04-24, accepted in 2014-10-29,  发布年份 2014

【 摘 要 】

Background

Current literature has elucidated a new phenotype, metabolically healthy obese (MHO), with risks of cardiovascular disease similar to that of normal weight individuals. Few studies have examined the MHO phenotype in an aging population, especially in association with subclinical CVD.

Research design and methods

This cross sectional study population consisted of 208 octogenarians and older. Anthropometrics, biochemical, and radiological parameters were measured to assess obesity, metabolic health (assessed by the National Cholesterol Education Program –Adult Treatment Panel (NCEP-ATP III) criteria), and subclinical measures of CVD.

Results

The prevalence of MHO was 13.5% (N = 28). No significant association with MHO was noted for age, coronary artery calcium score, cIMT, or hs-CRP > 3 mg/dl (p = NS).

Conclusions

Our results suggest that the MHO phenotype exists in the elderly; however, subclinical CVD measures were not different in sub-group analysis suggesting traditional metabolic risk factor algorithms may not be accurate in the very elderly.

【 授权许可】

   
2014 Roberson et al.; licensee BioMed Central Ltd.

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