Ingestion of a single serving of saury alters postprandial levels of plasma n-3 polyunsaturated fatty acids and long-chain monounsaturated fatty acids in healthy human adults

Lipids in Health and Disease

Masashi Katayama¹  Jiro Takeo¹  Hiroko Miyahara¹  Zhi-Hong Yang¹ 

[1]Central Research Laboratory, Tokyo Innovation Center, Nippon Suisan Kaisha, Ltd., 32-3 Nanakuni 1 Chome Hachioji, Tokyo, 192-0991, Japan

关键词: Docosahexaenoic acid (DHA);    Eicosapentaenoic acid (EPA);    MUFA;    n-3 PUFA;    Saury;   

Others  :  1160242
DOI  :  10.1186/1476-511X-11-95

 received in 2012-03-18, accepted in 2012-07-24,  发布年份 2012

【 摘 要 】

Background

Saury oil contains considerable amounts of n-3 polyunsaturated fatty acids (PUFA) and monounsaturated fatty acids (MUFA) with long aliphatic tails (>18C atoms). Ingestion of saury oil reduces the risk of developing metabolic syndrome concomitant with increases in n-3 PUFA and long-chain MUFA in plasma and organs of mice. We therefore evaluated changes in postprandial plasma fatty acid levels and plasma parameters in healthy human subjects after ingestion of a single meal of saury.

Findings

Five healthy human adults ingested 150 g of grilled saury. Blood was collected before the meal and at 2, 6, and 24 hr after the meal, and plasma was prepared. Plasma levels of eicosapentaenoic acid, docosahexaenoic acid, and long-chain MUFA (C20:1 and C22:1 isomers combined) increased significantly throughout the postprandial period compared with the pre-meal baseline. Postprandial plasma insulin concentration increased notably, and plasma levels of glucose and free fatty acids decreased significantly and subsequently returned to the pre-meal levels.

Conclusions

Our study suggests that a single saury meal may alter the postprandial plasma levels of n-3 PUFA and long-chain MUFA in healthy human subjects.

【 授权许可】

   
2012 Yang et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

Figure 4.

Figure 5.

【 参考文献 】

• [1]Delarue J, LeFoll C, Corporeau C, Lucas D: n-3 long chain polyunsaturated fatty acids: a nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity? Reprod Nutr Dev 2004, 44:289-299.
• [2]Wang C, Harris WS, Chung M, Lichtenstein AH, Balk EM, Kupelnick B, Jordan HS, Lau J: n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. Am J Clin Nutr 2006, 84:5-17.
• [3]Yurko-Mauro K: Cognitive and cardiovascular benefits of docosahexaenoic acid in aging and cognitive decline. Curr Alzhemier Res 2010, 7:190-196.
• [4]Fasano E, Serini S, Piccioni E, Innocenti I, Calviello G: Chemoprevention of lung pathologies by dietary n-3 polyunsaturated fatty acids. Curr Med Chem 2010, 17:3358-3376.
• [5]Calder PC: n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 2006, 83:1505S-1519S.
• [6]Yang ZH, Miyahara H, Mori T, Doisaki N, Hatanaka A: Beneficial effects of dietary fish-oil-derived monounsaturated fatty acids on metabolic syndrome risk factors and insulin resistance in mice. J Agric Food Chem 2011, 59:7482-7489.
• [7]Ota T, Takagi T, Kosaka S: Changes in lipids of young and adult saury cololabis saira (Pisces). Mar Ecol Prog Ser 1980, 3:11-17.
• [8]Oliveira ACM, Bechtel PJ: Lipid composition of Alaska pink salmon (Oncorhynchus gorbuscha) and Alaska walleye pollock (Theragra chalcogramma). J Aquat Food Prod Tech 2005, 14:73-91.
• [9]Yang ZH, Miyahara H, Takemura S, Hatanaka A: Dietary saury oil reduces hyperglycemia and hyperlipidemia in diabetic KKAy mice and in diet-induced obese C57BL/6J mice by altering gene expression. Lipids 2011, 46:425-434.
• [10]Yang ZH, Miyahara H, Takeo J, Hatanaka A, Katayama M: Pollock oil supplementation modulates hyperlipidemia and ameliorates hepatic steatosis in mice fed a high-fat diet. Lipids Health Dis 2011, 10:189. BioMed Central Full Text
• [11]Folch J, Lees M, Stanley GHS: A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1956, 226:497-509.
• [12]Jakobsson A, Westerberg R, Jacobsson A: Fatty acid elongases in mammals: Their regulation and roles in metabolism. Prog Lipid Res 2006, 45:237-249.
• [13]Bang HO, Dyerberg J, Sinclair HM: The composition of the Eskimo food in north western Greenland. Am J Clin Nutr 1980, 33:2657-2661.
• [14]Dyerberg J, Bang HO, Hjorne N: Fatty acid composition of the plasma lipids in Greenland Eskimos. Am J Clin Nutr 1975, 28:958-966.
• [15]Osterud B, Elvevoll E, Barstad H, Brox J, Halvorsen H, Lia K, Olsen JO, Olsen RO, Sissener C, Rekdal O, Vogild E: Effect of marine oils supplementation on coagulation and cellular activation in whole blood. Lipids 1995, 30:1111-1118.
• [16]Lafontan M, Langin D: Lipolysis and lipid mobilization in human adipose tissue. Prog Lipid Res 2009, 48:275-297.
• [17]Campbell PJ, Carlson MG, Hill JO, Nurjhan N: Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification. Am J Physiol 1992, 263:E1063-F1069.
• [18]López S, Bermúdez B, Pacheco YM, Villar J, Abia R, Muriana FJ: Distinctive postprandial modulation of beta cell function and insulin sensitivity by dietary fats: monounsaturated compared with saturated fatty acids. Am J Clin Nutr 2008, 88:638-644.