Regulation of Wnt/β-catenin signaling by posttranslational modifications

Cell & Bioscience

Jing Hu¹  Gutian Xiao¹  Chenxi Gao¹ 

[1] University of Pittsburgh Cancer Institute, Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Pittsburgh, PA 15213, USA

关键词: ADP-ribosylation;    Acetylation;    Sumoylation;    Ubiquitination;    Phosphorylaiton;    Posttranslational modification;    The Wnt/β-catenin pathway;   

Others  :  791067
DOI  :  10.1186/2045-3701-4-13

 received in 2013-11-13, accepted in 2014-01-07,  发布年份 2014

【 摘 要 】

The canonical Wnt signaling pathway (or Wnt/β-catenin pathway) plays a pivotal role in embryonic development and adult homeostasis; deregulation of the Wnt pathway contributes to the initiation and progression of human diseases including cancer. Despite its importance in human biology and disease, how regulation of the Wnt/β-catenin pathway is achieved remains largely undefined. Increasing evidence suggests that post-translational modifications (PTMs) of Wnt pathway components are essential for the activation of the Wnt/β-catenin pathway. PTMs create a highly dynamic relay system that responds to Wnt stimulation without requiring de novo protein synthesis and offer a platform for non-Wnt pathway components to be involved in the regulation of Wnt signaling, hence providing alternative opportunities for targeting the Wnt pathway. This review highlights the current status of PTM-mediated regulation of the Wnt/β-catenin pathway with a focus on factors involved in Wnt-mediated stabilization of β-catenin.

【 授权许可】

   
2014 Gao et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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Figure 3.

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