A case report of seronegative cat scratch disease, emphasizing the histopathologic point of view

Diagnostic Pathology

Kyung Jin Seo²  Su Yeon Kim¹  Tae Hee Han³  Taeseok Lim⁴  Tae-hyun Ban⁴  Yang Ree Kim⁴  Ok Ran Shin² 

[1] Division of Zoonoses (CJD/Rabies/LB), Center for Immunology & Pathology, National Institute of Health (Korea CDC), Seoul, Korea;Department of Hospital Pathology, Uijeongbu St. Mary’s Hospital College of Medicine, The Catholic University of Korea 271, Cheonbo-ro, Uijeongbu-si, Gyenggi-do 480-717, Republic of Korea;Department of Laboratory Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea;Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea

关键词: Differential diagnosis;    Histological features;    PCR;    Warthin-Starry silver stain;    Bartonella;    Cat scratch disease;   

Others  :  802276
DOI  :  10.1186/1746-1596-9-62

 received in 2014-03-04, accepted in 2014-03-12,  发布年份 2014

【 摘 要 】

Cat scratch disease, necrotizing granulomatous lymphadenitis caused by Bartonella henselae, usually benign and self-limited. However, various clinical manifestations and no pathognomonic histopathologic features can lead to misinterpretations and diagnostic disputes. We report a case of cat scratch disease in a 39-yr-old male patient with fever and left axillary lymphadenitis. He had a history of cat bite on the left hand dorsum. On excision, the lymph node showed follicular hyperplasia, stellate microabscesses with a rim of granulomatous inflammation. Warthin-Starry silver staining showed many clumps of silver-stained bacilli within the necrotic foci. Serological tests were negative. Diagnosis was established by PCR analysis.

【 授权许可】

   
2014 Shin et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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