Copeptin, a surrogate marker for arginine vasopressin, is associated with cardiovascular risk in patients with polycystic ovary syndrome

Journal of Ovarian Research

Tuncay Delibasi²  Muyesser Sayki Aslan²  Evrim Cakır¹  Nujen Colak Bozkurt²  Oya Topaloglu²  Melia Karakose²  Mustafa Ozbek²  Basak Karbek³ 

[1] Department of Endocrinology and Metabolic Diseases, Amasya Sabuncuoglu Serefettin Training and Research Hospital, Amasya, Turkey;Department of Endocrinology and Metabolic Diseases, Dışkapı Yıldırım Beyazıt Teaching and Research hospital, Ankara, Turkey;Department of Endocrinology and Metabolic Diseases, Gaziantep Dr. Ersin Arslan Hospital, Milli Egemenlik bulvarı, Sanlılar Apt, no:51 daire:9 Şehitkamil/Gaziantep, Gaziantep, Turkey

关键词: Cardiovascular disease risk;    Insulin resistance;    Carotid intima media thickness;    Copeptin;    Polycystic ovary syndrome;   

Others  :  801811
DOI  :  10.1186/1757-2215-7-31

 received in 2013-10-12, accepted in 2014-02-11,  发布年份 2014

【 摘 要 】

Background

Women with polycystic ovary syndrome (PCOS) have higher risk for cardiovascular disease (CVD). Copeptin has been found to be predictive for myocardial ischemia. We tested whether copeptin is the predictor for CVD in PCOS patients, who have an increased risk of cardiovascular disease.

Methods

This was a cross sectional controlled study conducted in a training and research hospital. The study population consisted of 40 reproductive-age PCOS women and 43 control subjects. We evaluated anthropometric and metabolic parameters, carotid intima media thickness and copeptin levels in both PCOS patients and control group.

Results

Mean fasting insulin, homeostasis model assessment insulin resistance index (HOMA-IR), triglyceride, total cholesterol, low density lipoprotein cholesterol (LDL-C), free testosterone, 17-OH progesterone, Dehydroepiandrosterone sulfate (DHEAS), carotid intima media thickness (CIMT) levels were significantly higher in PCOS patients. Mean copeptin level was in 12.61 ± 3.05 pmol/L in PCOS patients while mean copeptin level was 9.60 ± 2.80 pmol/L in healthy control women (p < 0.001). After adjustment for age and BMI, copeptin level was positive correlated with fasting insulin, free testosterone levels, CIMT, and HOM A-IR.

Conclusions

Copeptin appeared to have an important role in metabolic response and subsequent development of atherosclerosis in insulin resistant, hyperandrogenemic PCOS patients.

【 授权许可】

   
2014 Karbek et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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