期刊论文详细信息
Genetics Selection Evolution
Messenger RNA levels and transcription rates of hepatic lipogenesis genes in genetically lean and fat chickens
Madeleine Douaire1  Sandrine Lagarrigue1  Stéphanie Daval1 
[1] Laboratoire de génétique animale, Institut national de la recherche agronomique, École nationale supérieure agronomique de Rennes, 65 rue de Saint-Brieuc, 35042 Rennes Cedex, France
关键词: lipid metabolism;    transcription;    mRNA;    fatness;    chicken;   
Others  :  1094765
DOI  :  10.1186/1297-9686-32-5-521
 received in 2000-01-07, accepted in 2000-06-07,  发布年份 2000
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【 摘 要 】

Levels of body fat content in commercial meat chickens have prompted research in order to control the development of this trait. Based on experimentally selected divergent lean and fat lines, many studies have shown that liver metabolism has a major role in the fatness variability. In order to identify which genes are involved in this variability, we investigated the expression of several genes implicated in the hepatic lipid metabolism. The studied genes code for enzymes of fatty acid synthesis [ATP citrate-lyase (ACL), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), malic enzyme (ME), stearoyl-CoA desaturase (SCD1)], for an apolipoprotein [apolipoprotein A1 (APOA1)], and for the CCAAT/enhancer binding protein α (C/EBPα), which is a transcription factor implied in the regulation of several genes of lipid metabolism. The results show that the fat-line chickens display significantly higher hepatic transcription rates and mRNA levels than the lean-line chickens for the ACL, ME and APOA1 genes. This suggests that these genes could be responsible for the phenotypic fatness variability.

【 授权许可】

   
2000 INRA, EDP Sciences

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