The relative impact of vision impairment and cardiovascular disease on quality of life: the example of pseudoxanthoma elasticum

Health and Quality of Life Outcomes

Ecosse L Lamoureux³  Frank G Holz⁴  Hendrik PN Scholl¹  Peter Charbel Issa²  Manjula Marella⁵  Eva Fenwick⁵  Robert P Finger⁵ 

[1] Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;Nuffield Laboratory of Ophthalmology, University of Oxford, Level 5 and 6, West Wing, The John Radcliffe Hospital, Headley Way, OX3 9DU, Oxford, UK;Singapore Eye Research Institute, Singapore National Eye Centre, Singapore;Department of Ophthalmology, University of Bonn, Ernst-Abbe-Strasse 2. D-53127,Bonn, Germany;Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Peter Howson WingLevel 1, 32 Gisborne Street, East Melbourne VIC, 3002 Australia, University of Melbourne, Melbourne, Australia

关键词: SF-36;    Impact of Vision Impairment Questionnaire (IVI);    Pseudoxanthoma elasticum (PXE);    cardiovascular disease;    visual impairment;    health-related quality of life (HRQoL);    Vision-related quality of life (VRQoL);   

Others  :  826155
DOI  :  10.1186/1477-7525-9-113

 received in 2011-05-13, accepted in 2011-12-12,  发布年份 2011

【 摘 要 】

Objective

To investigate the impact of pseudoxanthoma elasticum (PXE), a rare hereditary disease of concurrent vision impairment (VI) and cardiovascular complications (CVCs), on vision-related (VRQoL) and health-related quality of life (HRQoL).

Methods

VRQoL and HRQoL were assessed using the Impact of Vision Impairment (IVI) questionnaire and the Short Form Health Survey (SF-36) in 107 PXE patients. Patients were stratified into four groups: A = no VI or CVC; B = CVCs only; C = VI only; and D = both VI and CVCs.

Results

Following Rasch analysis, the IVI was found to function as a vision-specific functioning and emotional well-being subscale, and the SF-36 as a health-related physical functioning and mental health subscale. The presence of VI and CVC were significant predictors of vision-specific functioning and emotional well-being (p < 0.001), with a clinically meaningful decrement in vision-specific functioning in patients with VI. No associations were found for the SF-36 Physical Functioning and Mental Health scores between any groups.

Conclusions

Vision impaired patients with PXE report significantly poorer vision-specific functioning than PXE patients without VI. In contrast, the relative impact of PXE on reported general HRQoL was much less. Our results suggest that vision impairment has the larger impact on QoL in this sample.

【 授权许可】

   
2011 Finger et al; licensee BioMed Central Ltd.

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