Is ABCC6 a genuine mitochondrial protein?

BMC Research Notes

Ludovic Martin²  Vincent Procaccio¹  Dominique Bonneau¹  Daniel Henrion³  Georges Lefthériotis²  Delphine Prunier-Mirebeau¹  Arnaud Chevrollier¹  Pascal Reynier¹  Marc Ferré¹ 

[1] Department of Biochemistry and Genetics, University Hospital, Angers, France;PXE Consultation Center, University Hospital, Angers, France;CNRS 6214/INSERM 1083, Angers University, Angers, France

关键词: Mitochondria-associated membrane (MAM);    Pseudoxanthoma elasticum (PXE);    ABCC6/MRP6;    Mitochondria;   

Others  :  1141321
DOI  :  10.1186/1756-0500-6-427

 received in 2013-02-15, accepted in 2013-10-11,  发布年份 2013

【 摘 要 】

Background

A recent article in Circulation Research suggests that the protein ABCC6, which when defective is responsible for pseudoxanthoma elasticum, an inherited condition with skin, eye and cardiovascular manifestations, is associated with dysfunction in mitochondria – Martin et al.: ABCC6 Localizes to the Mitochondria-Associated Membrane.Circ Res 2012, 111:516–520. We present complementary information based on a bioinformatics analysis, which was not performed in the article cited, to examine the suggestion that ABCC6 is localized to mitochondria.

Results

All the computational strategies and integrative approaches that constitute references in the field indicate that ABCC6 is localized outside of mitochondria.

Conclusion

Our computational and integrative results, including both experimental and predictive data, show that there is no support in favor of the localization of ABCC6 in mitochondria.

【 授权许可】

   
2013 Ferré et al.; licensee BioMed Central Ltd.

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