Co-occurrence of driver and passenger bacteria in human colorectal cancer

Gut Pathogens

Zhigang Zhang³  Qiang Guo⁵  Hailing Peng²  Hong Fan⁵  Xiao Liang¹  Xiaodan Tang⁵  Qingfang Song⁴  Jiawei Geng¹ 

[1] Department of Infectious Diseases, The First People’s Hospital of Yunnan Province, Kunming 650032, China;Medical Faculty, Kunming University of Science and Technology, Kunming 650500, China;State Key Laboratory of Genetic Resources and Evolution, Laboratory of Evolutionary & Functional Genomics, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China;Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Kunming 650032, China

关键词: Co-occurrence;    Passenger bacteria;    Driver bacteria;    CRC;   

Others  :  817344
DOI  :  10.1186/1757-4749-6-26

 received in 2014-05-18, accepted in 2014-06-22,  发布年份 2014

【 摘 要 】

Background

Both genetic and epigenetic alterations have been reported to act as driving forces of tumorigenesis in colorectal cancer (CRC), but a growing body of evidence suggests that intestinal microbiota may be an aetiological factor in the initiation and progression of CRC. Recently, the “driver-passenger” model for CRC has connected these different factors, but little has been done to characterize the CRC gut microbiome.

Findings

Building on the driver-passenger model, we used 454 pyrosequencing of bacterial 16S rRNA genes associated with 10 normal, 10 adenoma, and 8 tumor biopsy samples, and found 7 potential driver bacterial genera and 12 potential passenger bacterial genera (7 being pro-inflammatory and 5 anti-inflammatory). Further analysis also showed certain co-expression patterns among different clusters of bacteria that may potentially be related to the promotion or progression of gut cancers.

Conclusions

The present findings provide preliminary experimental evidence supporting the proposition of bacterial “driver-passenger model” for CRC, and identified potentially novel microbial agents that may be connected to risk of CRC in a Han Chinese population.

【 授权许可】

   
2014 Geng et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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