Immunopathogenesis of brain abscess

Journal of Neuroinflammation

Tammy Kielian¹ 

[1] Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA

关键词: neuroinflammation;    astrocytes;    microglia;    S. aureus;    brain abscess;   

Others  :  1213691
DOI  :  10.1186/1742-2094-1-16

 received in 2004-07-27, accepted in 2004-08-17,  发布年份 2004

【 摘 要 】

Brain abscess represents a significant medical problem despite recent advances made in detection and therapy. Due to the emergence of multi-drug resistant strains and the ubiquitous nature of bacteria, the occurrence of brain abscess is likely to persist. Our laboratory has developed a mouse experimental brain abscess model allowing for the identification of key mediators in the CNS anti-bacterial immune response through the use of cytokine and chemokine knockout mice. Studies of primary microglia and astrocytes from neonatal mice have revealed that S. aureus, one of the main etiologic agents of brain abscess in humans, is a potent stimulus for proinflammatory mediator production. Recent evidence from our laboratory indicates that Toll-like receptor 2 plays a pivotal role in the recognition of S. aureus and its cell wall product peptidoglycan by glia, although other receptors also participate in the recognition event. This review will summarize the consequences of S. aureus on CNS glial activation and the resultant neuroinflammatory response in the experimental brain abscess model.

【 授权许可】

   
2004 Kielian; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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