Neonatal lupus erythematosus: a cutaneous cases based update

Italian Journal of Pediatrics

Paola Coppo¹  Alberto Ricagni²  Emanuela Locatelli²  Valentina Tarasco²  Serena Viola²  Francesco Savino² 

[1] Department of Surgery, Dermatology Unit, Regina Margherita Children’s Hospital, University of Turin, Turin, Italy;Department of Pediatrics and Adolescence - Regina Margherita Children’s Hospital, Azienda Ospedaliera Città della Salute e della Scienza di Torino, University of Turin, Piazza Polonia, 94, Torino 10126, Italy

关键词: Skin lesions;    Antinuclear antibodies;    Neonatal lupus erythematosus;   

Others  :  1235252
DOI  :  10.1186/s13052-015-0208-5

 received in 2015-10-30, accepted in 2015-12-24,  发布年份 2016

【 摘 要 】

Background

Neonatal Lupus Erythematosus (NLE) is an uncommon autoimmune disease characterized by cutaneous, hepatic, hematological, neurological and cardiac involvement.

Case presentation

Here we report four cases of cutaneous NLE which were referred to our department in the last 10 years and update literature. The newborns presented with different skin, clinical and laboratory features. This underlines the phenotypic variability of NLE. We investigated the passage of maternal antinuclear antibodies (ANA) and extractable nuclear antigen antibodies (ENA) - particularly anti-Ro/SSA, anti-La/SSB and anti-U1 ribonucleoprotein RNP - through the placenta. Despite the positive family background, cutaneous NLE and serological data improved in infants within 4 months without treatment.

Conclusion

The evolution of cutaneous NLE may be the spontaneous regression of lesions within six months without progression to Systemic Lupus Erytehmatosus.

【 授权许可】

   
2016 Savino et al.

【 图 表 】

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