A newborn with grouped facial skin lesions and subsequent seizures

BMC Pediatrics

Rangmar Goelz¹  Christian Friedrich Poets¹  Rupert Handgretinger⁴  Marko Wilke²  Wolfgang Buchenau¹  Ilias Tsiflikas³  Karin Melanie Rohrer⁴  Michaela Döring⁴ 

[1] Department IV – Neonatology, University Hospital Tuebingen, Children’s Hospital, Calwerstr. 7, Tuebingen 72076, Germany;Department III – Neuropaediatrics, Developmental Neurology, Social Paediatrics, University Hospital Tuebingen, Children’s Hospital, Hoppe-Seyler-Str.1, Tuebingen 72076, Germany;Department of Radiology, Diagnostic and Interventional Radiology, University Hospital Tuebingen, Hoppe-Seyler-Str. 3, Tuebingen 72076, Germany;Department I – General Paediatrics, Hematology/Oncology, University Hospital Tuebingen, Children’s Hospital, Hoppe-Seyler-Str.1, Tuebingen 72076, Germany

关键词: Seizure;    Neonatal lupus erythematosus;    Mixed connective tissue disease;    Congenital grouped skin lesions;   

Others  :  1138858
DOI  :  10.1186/1471-2431-14-126

 received in 2014-02-12, accepted in 2014-05-19,  发布年份 2014

【 摘 要 】

Background

Congenital grouped skin lesions are alarming signs of a variety of threatening diagnoses of quite different origin. The present case report shows an impressive clinical pattern of a neonate and illustrates the difficulty in differential diagnosis of mixed connective tissue disease and neonatal lupus erythematosus in newborns. This reported case is to our knowledge the first description of an unrecognized mixed connective tissue disease in the mother with an unusual clinical manifestation in the newborn, comprising skin lesions, neurological damage and non-typical antibody constellation.

Case presentation

We report on a Caucasian female neonate from a perinatally asymptomatic mother, who presented with grouped facial pustular-like skin lesions, followed by focal clonic seizures caused by multiple ischemic brain lesions. Herpes simplex virus infection was excluded and both the mother and her infant had the antibody pattern of systemic lupus erythematosus and neonatal lupus erythematosus, respectively. However, clinical signs in the mother showed overlapping features of mixed connective tissue disease.

Conclusion

This case report emphasizes congenital Lupus erythematosus and mixed connective tissue disease as important differential diagnoses of grouped skin lesions in addition to Herpes simplex virus-infection. The coexistence of different criteria for mixed connective tissue disease makes it difficult to allocate precisely maternal and congenital infantile disease.

【 授权许可】

   
2014 Döring et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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