期刊论文详细信息
BMC Veterinary Research
Contrast-enhanced ultrasonography of the pancreas in healthy cats
Marco BaronToaldo2  Annamaria Grandis2  Federico Fracassi2  Joerg M Steiner1  Valeria Fedone3  Mario Cipone2  Nikolina Linta2  Alessia Diana2 
[1] Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA;Department of Veterinary Medical Sciences, Alma Mater Studiorum – University of Bologna, Via Tolara di Sopra 50, Bologna, I-40064, Ozzano Emilia, Italy;Freelance sonographer, Messina, Italy
关键词: Sonovue;    Pancreas;    Diagnostic ultrasound;    Contrast-enhanced ultrasonography;    Cat;   
Others  :  1140513
DOI  :  10.1186/s12917-015-0380-2
 received in 2014-09-22, accepted in 2015-02-27,  发布年份 2015
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【 摘 要 】

Background

This study describes the pattern of ultrasonographic contrast enhancement of the pancreatic body and left lobe using a second-generation commercial contrast medium (Sonovue) in 10 clinically healthy cats.

Results

Following contrast medium administration, microbubbles were observed within the splenic artery. This was followed by an inflow of contrast medium into the pancreatic capillary beds, providing a uniformly contrast-enhanced pancreas at peak intensity (PI). At the time of PI, a replenishment of the splenic and portal veins started and increased progressively during the wash-out phase. During the wash-out phase, the echogenicity of the pancreatic parenchyma decreased progressively. Perfusion parameters included arrival time (4.69 ± 1.26 s), time to peak from injection (7.52 ± 1.88 s), time to peak from initial rise (2.84 ± 0.88 s), peak intensity (6.58 ± 2.66 a.u.), and wash-in rate (2.11 ± 1.79 a.u./s).

Conclusions

This perfusion pattern of normal pancreatic parenchyma may be useful for characterising cats with exocrine pancreatic disorders.

【 授权许可】

   
2015 Diana et al.; licensee BioMed Central.

【 预 览 】
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【 参考文献 】
  • [1]Larson MM, Panciera DL, Ward DL, Steiner JM, Williams DA: Age-related changes in the ultrasound appearance of the normal feline pancreas. Vet Radiol Ultrasound 2005, 46:238-42.
  • [2]Hecht S, Henry G: Sonographic evaluation of the normal and abnormal pancreas. Clin Tech Small Anim Pract 2007, 22:115-21.
  • [3]Hecht S, Penninck DG, Mahony OM, King R, Rand WM: Relationship of pancreatic duct dilation to age and clinical findings in cats. Vet Radiol Ultrasound 2006, 47:287-94.
  • [4]Etue SM, Penninck DG, Labato MA, Pearson S, Tidwell A: Ultrasonography of the normal feline pancreas and associated anatomic landmarks: a prospective study of 20 cats. Vet Radiol Ultrasound 2001, 42:330-6.
  • [5]Forman MA, Marks SL, De Cock HE, Hergesell EJ, Wisner ER, Baker TW, et al.: Evaluation of serum feline pancreatic lipase immunoreactivity and helical computed tomography versus conventional testing for the diagnosis of feline pancreatitis. J Vet Intern Med 2004, 18:807-15.
  • [6]Hecht S, Penninck DG, Keating JH: Imaging findings in pancreatic neoplasia and nodular hyperplasia in 19 cats. Vet Radiol Ultrasound 2007, 48:45-50.
  • [7]Mansfield CS, Jones BR: Review of feline pancreatitis part two: clinical signs, diagnosis and treatment. J Feline Med Surg 2001, 3:125-32.
  • [8]Ferreri JA, Hardman E, Kimmel SE, Saunders HM, Van Winkle TJ, Drobatz KJ, et al.: Clinical differentiation of acute necrotizing from chronic non suppurative pancreatitis in cats: 63 cases (1996–2001). J Am Vet Med Assoc 2003, 223:469-74.
  • [9]Williams JM, Panciera DL, Larson MM, Were SR: Ultrasonographic findings of the pancreas in cats with elevated serum pancreatic lipase immunoreactivity. J Vet Intern Med 2013, 27:913-8.
  • [10]Gerhardt A, Steiner JM, Williams DA: Comparison of the sensitivity of different diagnostic tests for pancreatitis in cats. J Vet Intern Med 2011, 5:329-33.
  • [11]Saunders HM, Van Winkle TJ, Drobatz K, Kimmel SE, Washabau RJ: Ultrasonographic findings in cats with clinical, gross pathologic, and histologic evidence of acute pancreatic necrosis: 20 cases (1994–2001). J Am Vet Med Assoc 2002, 221:1724-30.
  • [12]D’Onofrio M, Zamboni G, Faccioli N, Capelli P, Pozzi Mucelli R: Ultrasonography of the pancreas. 4. Contrast-enhanced imaging. Abdom Imaging 2007, 32:171-81.
  • [13]Kersting S, Konopke R, Kersing F, Volk A, Distler M, Bergert H, et al.: Quantitative perfusion analysis of transabdominal contrast-enhanced ultrasonography of pancreatic mass and carcinomas. Gastroenterology 2009, 137:1903-11.
  • [14]D’Onofrio M, Gallotti A, Principe F, Mucelli RP: Contrast-enhanced ultrasound of the pancreas. World J Radiol 2010, 2:97-102.
  • [15]Serra C, Felicani C, Mazzotta E, Piscitelli L, Cipollini ML, Tomassetti P, et al.: Contrast-enhanced ultrasound in the differential diagnosis of exocrine versus neuroendocrine pancreatic tumors. Pancreas 2013, 42:871-7.
  • [16]Chen F, Liang JY, Zhao QY, Wang LY, Li J, Deng Z, et al.: Differentiation of branch duct intraductal papillary mucinous neoplasms from serous cystadenomas of the pancreas using contrast-enhanced sonography. J Ultrasound Med 2014, 33:449-55.
  • [17]Ripollé T, Martinez MJ, López E, Castello I, Delgado F: Contrast-enhanced ultrasound in the staging of acute pancreatitis. Eur Radiol 2010, 20:2518-23.
  • [18]Andersen AM, Malmstrøm ML, Novovic S, Nissen FH, Jensen LI, Holm O, et al.: Contrast enhanced ultrasonography in acute pancreatitis. Pancreatology 2013, 13:95-7.
  • [19]Rademacher N, Ohlerth S, Scharf G, Laluhova D, Sieber-Ruckstuhl N, Alt M, et al.: Contrast-enhanced power and color Doppler ultrasonography of the pancreas in healthy and diseased cats. J Vet Intern Med 2008, 22:1310-6.
  • [20]Leinonen MR, Raekallio MR, Vainio OM, Ruohoniemi MO, Biller DS, O’Brien RT: Quantitative contrast-enhanced ultrasonographic analysis of perfusion in the kidneys, liver, pancreas, small intestine, and mesenteric lymph nodes in healthy cats. Am J Vet Res 2010, 71:1305-11.
  • [21]Johnson-Neitman JL, O’Brien RT, Wallace JD: Quantitative perfusion analysis of the pancreas and duodenum in healthy dogs by use of contrast-enhanced ultrasonography. Am J Vet Res 2012, 73:385-92.
  • [22]Lim SY, Nakamura K, Morishita K, Sasaki N, Murakami M, Osuga T, et al.: Qualitative and quantitative contrast enhanced ultrasonography of the pancreas using bolus injection and continuous infusion methods in normal dogs. J Vet Med Sci 2013, 2013(75):1601-7.
  • [23]Lim SY, Nakamura K, Morishita K, Sasaki N, Murakami M, Osuga T, et al.: Qualitative and quantitative contrast-enhanced ultrasonographic assessment of cerulein-induced acute pancreatitis in dogs. J Vet Intern Med 2014, 28:496-503.
  • [24]Vanderperren K, Haers H, Van der Vekens E, Stock E, Paepe D, Daminet S, et al.: Description of the use of contrast-enhanced ultrasonography in four dogs with pancreatic tumours. J Small Anim Pract 2014, 55:164-9.
  • [25]Evans HE, De Lahunta A: The heart and arteries. In Miller’s Anatomy of the Dog. 4th edition. Elsevier Saunders, St. Louis, MO; 2012:428-504.
  • [26]Gomerčić H, Babić K: Variations of the arterial supply of the duodenum and the pancreas in the domestic cat (Felis domestica Brisson). Acta Anat 1975, 91:213-21.
  • [27]Crough JE: The blood vessels. In Text-Atlas of Cat Anatomy. Lea and Febiger, Philadelphia, PA; 1969:203-60.
  • [28]Leinonen MR, Raekallio MR, Vainio OM, O’Brien RT: Effect of anaesthesia on contrast-enhanced ultrasound of the feline spleen. Vet J 2011, 190:273-7.
  • [29]Leinonen MR, Raekallio MR, Vainio OM, Ruohoniemi MO, O’Brien RT: The effect of the sample size and location on contrast ultrasound measurement of perfusion parameters. Vet Radiol Ultrasound 2010, 52:82-7.
  • [30]Diana A, Specchi S, Baron Toaldo M, Chiocchetti R, Laghi A, Cipone M: Contrast-enhanced ultrasonography of the small bowel in healthy cats. Vet Radiol Ultrasound 2011, 52:555-9.
  • [31]Dietrich CF, Ignee A, Hocke M, Schreiber-Dietrich D, Greis C: Pitfalls and artefacts using contrast enhanced ultrasound. Z Gastroenterol 2011, 49:350-6.
  • [32]Dietrich CF, Ignee A, Greis C, Cui XW, Schreiber-Dietrich DG, Hocke M: Artifacts and pitfalls in contrast-enhanced ultrasound of the liver. Ultraschall Med 2014, 35:108-25.
  • [33]Yu H, Jang HJ, Kim TK, Khalili K, Williams R, Leuck G, et al.: Pseudoenhancement within the local ablation zone of hepatic tumors due to a nonlinear artefact on contrast-enhanced ultrasound. AJR Am J Roentgenol 2010, 194:653-9.
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