The changing pattern of ano-rectal cancer, squamous cell carcinoma of the eye, and Hodgkin’s lymphoma as non-AIDS-defining cancers, by HIV status, in Tanzania over 11 years (2002-2012): a retrospective case-report study

Infectious Agents and Cancer

Sofia D Merajver³  Julius Mwaiselage²  Crispin Kahesa²  Twalib Ngoma²  Amr S Soliman¹  Clare Meernik³ 

[1] Department of Epidemiology, University of Nebraska Medical Center College of Public Health, Omaha, NE, USA;Ocean Road Cancer Institute, Dar es Salaam, Tanzania;Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA

关键词: Ocean Road Cancer Institute;    Squamous cell carcinoma of the eye;    Tanzania;    HIV;    Non-AIDS-defining cancer;   

Others  :  1133754
DOI  :  10.1186/1750-9378-9-42

 received in 2014-08-22, accepted in 2014-11-03,  发布年份 2014

【 摘 要 】

Background

In Tanzania, 5.1% of adults aged 15-49 are infected with HIV. While rates of HIV-related malignancies have declined globally with antiretroviral therapy (ART), including Tanzania, rates of non-AIDS-defining cancers (NADCs) are believed to have increased. Therefore, we determined trends of three NADCs in Tanzania: ano-rectal cancer, squamous cell carcinoma of the eye, and Hodgkin’s lymphoma.

Methods

This study was conducted at the Ocean Road Cancer Institute (ORCI) in Dar es Salaam. All medical records of patients diagnosed with ano-rectal cancer, squamous cell carcinoma of the eye, and Hodgkin’s lymphoma between 2002 and 2012 were reviewed regarding HIV status, cancer clinical characteristics and management. Analysis was conducted to determine trends and proportions in these three NADCs and patient characteristics.

Results

We identified 980 NADCs. The relative proportion of these three NADCs at ORCI out of all cancers treated increased from 2.37% in 2002 to a peak of 4.34% in 2009. The prevalence of HIV in patients diagnosed with these NADCs also increased—from 6.67% in 2002 to 20.87% in 2010—and 85% of squamous cell carcinoma of the eye cancer patients with a reported HIV status were HIV-positive.

Conclusions

The frequency and proportions of these three NADCs in Tanzania have increased over the past 11 years, as has the prevalence of HIV positivity amongst these NADC patients. The current and possibly increasing burden of NADCs in Tanzania and other low- and middle-income countries with high HIV rates should be a focus for future cancer prevention and control and HIV therapy programs.

【 授权许可】

   
2014 Meernik et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

【 参考文献 】

• [1]Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F: GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11. [http://globocan.iarc.fr webcite]
• [2]American Cancer Society: Cancer in Africa. [http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-031574.pdf webcite]
• [3]De Martel C, Ferlay J, Franceschi S, Vignat J, Bray F, Forma D, Plummer M: Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol 2012, 13:607-615.
• [4]World Health Organization: Ten Facts on HIV/AIDS. [http://www.who.int/features/factfiles/hiv/en/index.html webcite]
• [5]Tanzania HIV/AIDS and Malaria Indicator Survey 2011-2012. [http://dhsprogram.com/pubs/pdf/AIS11/AIS11.pdf webcite]
• [6]Shiels M, Pfeiffer R, Gail M, Hall HI, Li J, Chaturvedi AK, Bhatia K, Uldrick TS, Yarchoan R, Goedert JJ, Engels A: Cancer burden in the HIV-infected population in the United States. J Natl Cancer Inst 2011, 103:753-762.
• [7]Chokunonga E, Levy LM, Bassett MT, Mauchaza BG, Thomas DB, Parkin DM: Cancer incidence in the African population of Harare, Zimbabwe: second results from the cancer registry 1993–1995. Int J Cancer 2000, 85:54-59.
• [8]Mbulaiteye S, Bhatia K, Adebamowo C, Sasco AJ: HIV and cancer in Africa: mutual collaboration between HIV and cancer programs may provide timely research and public health data. Infect Agents Cancer 2011, 6:16. BioMed Central Full Text
• [9]Koski L, Ngoma T, Mwaiselage J, Le L, Soliman AS: Changes in the pattern of Kaposi’s sarcoma at Ocean Road Cancer Institute in Tanzania (2006-2011). Int J STD AIDSin press
• [10]Yanik EL, Napravnik S, Cole SR, Achenbach CJ, Gopal S, Dittmer DP, Olshan AF, Kitahata MM, Mugavero MJ, Saag M, Moore RD, Matthews WC, Hunt P, Eron JJ: Relationship of immunologic response to antiretroviral therapy with non-AIDS defining cancer incidence. AIDS 2014, 28:979-987.
• [11]Mbulaiteye SM, Katabira ET, Wabinga H, Parkin DM, Virgo P, Ochai R, Workneh M, Coutinho A, Engels EA: Spectrum of cancers among HIV-infected persons in Africa: the Uganda AIDS-Cancer Registry Match Study. Int J Cancer 2006, 118:985-990.
• [12]Akarolo-Anthony SN, Dal Maso L, Igbinoba F, Mbulaiteye SM, Adebamowo CA: Cancer burden among HIV-positive persons in Nigeria: preliminary findings from the Nigerian AIDS-cancer match study. Infect Agents Cancer 2014, 9:1. BioMed Central Full Text
• [13]Stebbing J, Duru O, Bower M: Non-AIDS-defining cancer. Curr Opin Infect Dis 2009, 22:7-10.
• [14]Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Cancer J Clin 2011, 61:69-90.
• [15]Herida M, Mary-Krause M, Kaphan R, Cadranel J, Poizot-Martin I, Rabaud C, Plaisance N, Tissot-Dupont H, Boue F, Lang JM, Costagliola D: Incidence of non-AIDS-defining cancers before and during the highly active antiretroviral therapy era in a cohort of human immunodeficiency virus-infected patients. J Clin Oncol 2003, 21:3447-3453.
• [16]Powles T, Robinson D, Stebbing J, Shamash J, Nelson M, Gazzard B, Mandelia S, Moller H, Bower M: Highly active antiretroviral therapy and the incidence of non-AIDS-defining cancers in people with HIV infection. J Clin Oncol 2009, 27:884-890.
• [17]United Nations, Department of Economic and Social Affairs. Population Division, Population Estimates and Projections Section: World Population Prospects: The 2012 Revision. [http://esa.un.org/unpd/wpp/Excel-Data/population.htm webcite]
• [18]Forman D, Bray F, Brewster DH, Gombe Mbalawa C, Kohler B, Pineros M, Steliarova-Foucher E, Swaminathan R, Ferlay J (Eds): Cancer incidence in five continents, vol X (electronic version) Lyon: IARC; [http://ci5.iarc.fr webcite]
• [19]Engels EA, Pfeiffer RM, Goedert JJ, Virgo P, McNeel TS, Scoppa SM, Biggar RJ: Trends in cancer risk among people with AIDS in the United States 1980-2002. AIDS 2006, 20:1645-1654.
• [20]Frisch M, Biggar RJ, Engels EA, Goedert JJ, AIDS-Cancer Match Registry Study Group: Association of cancer with AIDS-related immunosuppression in adults. JAMA 2001, 285:1736-1745.
• [21]Biggar RJ, Chaturvedi AK, Goedert JJ, Engels EA: AIDS-related cancer and severity of immunosuppression in persons with AIDS. JNCI 2007, 99:962-972.
• [22]Calabresi A, Ferraresi A, Festa A, Scarcella C, Donato F, Vassallo F, Limina RM, Castelli F, QuirosRoldan E: Incidence of AIDS-defining cancers and virus-related and non-virus-related non-AIDS-defining cancers among HIV-infected patients compared with the general population of Northern Italy, 1999-2009. HIV Med 2013, 14:481-490.
• [23]Sasco AJ, Jaquet A, Boidin E, Ekouevi DK, Thouillot F, LeMabec T, Forstin MA, Renaudier P, N’Dom P, Malvy D, Dabis F: The challenge of AIDS-related malignancies in sub-Saharan Africa. PLoS One 2010, 5:e8621.
• [24]Crum-Cianflone N, Hullsiek KH, Marconi V, Weintrob A, Ganesan A, Barthel RV, Fraser S, Agan BK, Wegner S: Trends in the incidence of cancers among HIV-infected persons and the impact of antiretroviral therapy: a 20-year cohort study. AIDS 2009, 23:41-50.
• [25]Burgi A, Brodine S, Wegner S, Milazzo M, Wallace MR, Spooner K, Blazes DL, Agan BK, Armstrong A, Fraser S, Crum NF: Incidence and risk factors for the occurrence of non-AIDS-defining cancers among human immunodeficiency virus-infected individuals. Cancer 2005, 104:1505-1511.
• [26]Dauby N, De Wit S, Delforge M, Necsoi VC, Clumeck N: Characteristics of non-AIDS-defining malignancies in the HAART era: a clinic-epidemiological study. J Int AIDS Soc 2011, 14:16. BioMed Central Full Text
• [27]Deeken JF, Tjen-A-Looi A, Rudek MA, Okuliar C, Young M, Little RF, Dezube BJ: The rising challenge of non-AIDS-defining cancers in HIV-infected patients. Clin Infect Dis 2012, 55:1228-12335.
• [28]Waddell KM, Lewallen S, Lucas SB, Atenyi-Agaba , Herrington CS, Liomba G: Carcinoma of the conjunctiva and HIV infection in Uganda and Malawi. Br J Opthalmol 1996, 80:503-508.
• [29]Sun EC, Fears TR, Goedert JJ: Epidemiology of squamous cell conjunctival cancer. Cancer Epidemiol Biomarkers Prev 1997, 6:73-77.
• [30]Guech-Ongey M, Engels EA, Goedert JJ, Biggar RJ, Mbulaiteye SM: Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United States. Int J Cancer 2008, 122:2590-2593.
• [31]Frisch M, Biggar RJ, Goedert JJ: Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. J Natl Cancer Inst 2000, 92:1500-1510.
• [32]Cleator S, Fife K, Nelson M, Gazzard B, Phillips R, Bower M: Treatment of HIV-associated invasive anal cancer with combined chemoradiation. Eur J Cancer 2000, 36:754-758.
• [33]Hoffman R, Welton ML, Klencke B, Weinberg V, Krieg R: The significance of pretreatment CD4 count on the outcome and treatment tolerance of HIV-positive patients with anal cancer. Int J Radiat Oncol Biol Phys 1997, 37:1101-1105.
• [34]Coghill AE, Newcomb PA, Madeleine MM, Richardson BA, Mutyaba I, Okuku F, Phipps W, Wabinga H, Orem J, Casper C: Contribution of HIV infection to mortality among cancer patients in Uganda. AIDS 2013, 27:2933-2942.
• [35]African Cancer Registry Network: Tanzania Cancer Registry. [http://www.afcrn.org/membership/members/114-tanzania webcite]
• [36]National Cancer Institute: Joinpoint Regression Program, Version 4.0.4. [http://surveillance.cancer.gov/joinpoint/ webcite]