Conflict and Health | |
Neonatal survival in complex humanitarian emergencies: setting an evidence-based research agenda | |
Ribka Amsalu3  Samira Sami5  Curtis Blanton5  Joy Lawn1  Barbara Tomczyk5  Kate Kerber4  Diane F Morof2  | |
[1] Epidemiology, London School of Hygiene and Tropical Medicine, Global Evidence and Policy, Saving Newborn Lives, Save the Children, Keppel Street, London WCIE-7HT, UK;Division of Reproductive Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, MS-F-74, Atlanta, GA 30341, USA;Save the Children, 54 Wilton Road, Westport, CT 06880, USA;University of the Western Cape, Bellville 7535, South Africa;Emergency Response and Recovery Branch, Centers for Disease Control and Prevention, 4770 Buford Hwy, MS-F-57, Atlanta 30341GA,USA | |
关键词: Complex humanitarian emergency; Millennium development goals; Epidemiology; Inequity; Birth asphyxia; Preterm birth; Neonatal infections; Priority-setting; Research; Newborn; Neonatal; | |
Others : 803359 DOI : 10.1186/1752-1505-8-8 |
|
received in 2014-02-02, accepted in 2014-05-11, 发布年份 2014 | |
【 摘 要 】
Background
Over 40% of all deaths among children under 5 are neonatal deaths (0–28 days), and this proportion is increasing. In 2012, 2.9 million newborns died, with 99% occurring in low- and middle-income countries. Many of the countries with the highest neonatal mortality rates globally are currently or have recently been affected by complex humanitarian emergencies. Despite the global burden of neonatal morbidity and mortality and risks inherent in complex emergency situations, research investments are not commensurate to burden and little is known about the epidemiology or best practices for neonatal survival in these settings.
Methods
We used the Child Health and Nutrition Research Initiative (CHNRI) methodology to prioritize research questions on neonatal health in complex humanitarian emergencies. Experts evaluated 35 questions using four criteria (answerability, feasibility, relevance, equity) with three subcomponents per criterion. Using SAS 9.2, a research prioritization score (RPS) and average expert agreement score (AEA) were calculated for each question.
Results
Twenty-eight experts evaluated all 35 questions. RPS ranged from 0.846 to 0.679 and the AEA ranged from 0.667 to 0.411. The top ten research priorities covered a range of issues but generally fell into two categories– epidemiologic and programmatic components of neonatal health. The highest ranked question in this survey was “What strategies are effective in increasing demand for, and use of skilled attendance?”
Conclusions
In this study, a diverse group of experts used the CHRNI methodology to systematically identify and determine research priorities for neonatal health and survival in complex humanitarian emergencies. The priorities included the need to better understand the magnitude of the disease burden and interventions to improve neonatal health in complex humanitarian emergencies. The findings from this study will provide guidance to researchers and program implementers in neonatal and complex humanitarian fields to engage on the research priorities needed to save lives most at risk.
【 授权许可】
2014 Morof et al.; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
20140708040641317.pdf | 234KB | download |
【 参考文献 】
- [1]Lawn JE, Kinney MV, Black RE, Pitt C, Cousens S, Kerber K, Corbett E, Moran AC, Morrissey CS, Oestergaard MZ: Newborn survival: a multi-country analysis of a decade of change. Health Policy Plan 2012, Supplement 3:1-23.
- [2]UNICEF: Levels & Trends in Child Mortality. Estimates Developed by the UN Inter-Agency Group for Child Mortality Estimation. New York: UNICEF, the World Health Organization, the World Bank, and the United Nations Population Division; 2013.
- [3]Lawn JE, Cousens S, Zupan J: 4 million neonatal deaths: when? Where? Why? Lancet 2005, 365(9462):891-900.
- [4]Lawn JE, Lee AC, Kinney M, Sibley L, Carlo WA, Paul VK, Pattinson R, Darmstadt GL: Two million intrapartum-related stillbirths and neonatal deaths: where, why, and what can be done? Int J Gynaecol Obstet 2009, 107 Suppl 1:S5-S18. S19
- [5]Save the Children: Surviving the First Day: State of the Worlds Mothers. 2013. [cited 2013 May 20]; Available from: http://www.savethechildrenweb.org/SOWM-2013/#/1/ webcite
- [6]Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, Rudan I, Campbell H, Cibulskis R, Li M, Mathers C, Black RE: Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet 2012, 379(9832):2151-2161.
- [7]Darmstadt GL, Bhutta ZA, Cousens S, Adam T, Walker N, de Bernis L, Lancet Neonatal Survival Steering Team: Evidence-based, cost-effective interventions: how many newborn babies can we save? Lancet 2005, 365(9463):977-988.
- [8]Shiffman J: Issue attention in global health: the case of newborn survival. Lancet 2010, 375(9730):2045-2049.
- [9]Lozano R, Wang H, Foreman KJ, Rajaratnam JK, Naghavi M, Marcus JR, Dwyer-Lindgren L, Lofgren KT, Phillips D, Atkinson C, Lopez AD, Murray CJ: Progress towards Millennium Development Goals 4 and 5 on maternal and child mortality: an updated systematic analysis. Lancet 2011, 378(9797):1139-1165.
- [10]Rajaratnam JK, Marcus JR, Flaxman AD, Wang H, Levin-Rector A, Dwyer L, Costa M, Lopez AD, Murray CJ: Neonatal, postneonatal, childhood, and under-5 mortality for 187 countries, 1970–2010: a systematic analysis of progress towards Millennium Development Goal 4. Lancet 2010, 375(9730):1988-2008.
- [11]UNICEF: The state of the World’s Children 2011: Adolescence an Age of Opportunity. New York: U.N. Publications, Editor; 2011.
- [12]UNICEF: Levels and Trends in Child Mortality Report 2012: Estimates Developed by the UN Inter-Agency Group for Child Mortality Estimation. New York: UNICEF, the World Health Organization, the World Bank, and the United Nations Population Division; 2012.
- [13]Uppsala Universitat: UCDP/PRIO Armed Conflict Dataset v.4-2011, 1946 – 2010. 2010. [cited 2012 March 20]; Available from: http://www.pcr.uu.se/research/ucdp/datasets/ucdp_prio_armed_conflict_dataset/ webcite
- [14]Strand H, Dahl M: Defining Conlict-Affected Countries, in Education for All Global Monitoring Report 2011The hidden crisis: Armed conflict and education. UNESCO, Editor; 2010. http://unesdoc.unesco.org/images/0019/001907/190711e.pdf webcite
- [15]Lam JO, Amsalu R, Kerber K, Lawn JE, Tomczyk B, Cornier N, Adler A, Golaz A, Moss WJ: Neonatal survival interventions in humanitarian emergencies: a survey of current practices and programs. Confl Heal 2012, 6(1):2. BioMed Central Full Text
- [16]Toole MJ, Waldman RJ: The public health aspects of complex emergencies and refugee situations. Annu Rev Public Health 1997, 18:283-312.
- [17]United Nations High Commissioner for Refugees: The Refugee Story in Data and Statistics. Statistics & Operational Data mid-2013; [cited 2014 April 2014]; Available from: http://www.unhcr.org/pages/49c3646c4d6.html webcite
- [18]United Nations Population Fund: State of the World’s Population. 2011. [cited 2012 March 20]; Available from: http://www.unfpa.org/swp/ webcite
- [19]Jamieson DJ, Meikle SF, Hillis SD, Mtsuko D, Mawji S, Duerr A: An evaluation of poor pregnancy outcomes among Burundian refugees in Tanzania. JAMA 2000, 283(3):397-402.
- [20]Moss WJ, Ramakrishnan M, Storms D, Henderson Siegle A, Weiss WM, Lejnev I, Muhe L: Child health in complex emergencies. Bull World Health Organ 2006, 84(1):58-64.
- [21]Austin J, Guy S, Lee-Jones L, McGinn T, Schlecht J: Reproductive health: a right for refugees and internally displaced persons. Reprod Health Matters 2008, 16(31):10-21.
- [22]McGinn T, Purdin S: Editorial: Reproductive health and conflict: looking back and moving ahead. Disasters 2004, 28(3):235-238.
- [23]Salama P, Spiegel P, Talley L, Waldman R: Lessons learned from complex emergencies over past decade. Lancet 2004, 364(9447):1801-1813.
- [24]Inter-Agency Working Group on Reproductive Health in Crises: Inter-agency Field Manual on Reproductive Health in Humanitarian Settings: 2010. 2010. Available from: http://www.iawg.net/resources/field_manual.html webcite
- [25]The Sphere Project: Humanitarian Charter and Minimum Standards in Humanitarian Response. 2011. [cited 2012 December 31]; Available from: http://www.sphereproject.org/ webcite
- [26]Measure DHS: Demographic and Health Surveys (DHS). Available from: http://www.measuredhs.com/ webcite
- [27]UNICEF: Multiple Indicator Cluster Survey (MICS). Available from: http://www.unicef.org/statistics/index_24302.html webcite
- [28]Centre for Research on the Epidemiology of Disasters: EM-DAT The International Disaster Database. Available from: http://www.emdat.be/database webcite
- [29]Rudan I, Chopra M, Kapiriri L, Gibson J, Ann Lansang M, Carneiro I, Ameratunga S, Tsai AC, Chan KY, Tomlinson M, Hess SY, Campbell H, El Arifeen S, Black RE: Setting priorities in global child health research investments: universal challenges and conceptual framework. Croat Med J 2008, 49(3):307-317.
- [30]Child Health and Nutrition Research Initiative (CHNRI): About Chnri. 2005. [cited 2012 March 20]; Available from: http://chnri.org/about.php webcite
- [31]Rudan I, el Arifeen S, RE B: A Systematic Methodology for Setting Priorities in Child Health Research Investments. Dhaka: Child Health and Nutrition Research Initiative; 2006. [A new approach for systematic priority setting, Editor]
- [32]George A, Young M, Bang A, Chan KY, Rudan I, Victora CG, Chopra M, Rubens C, Gapps Expert Group on Community Based Strategies Constraints: Setting implementation research priorities to reduce preterm births and stillbirths at the community level. PLoS Med 2011, 8(1):e1000380.
- [33]Cousens S, Blencowe H, Stanton C, Chou D, Ahmed S, Steinhardt L, Creanga AA, Tunçalp O, Balsara ZP, Gupta S, Say L, Lawn JE: National, regional, and worldwide estimates of stillbirth rates in 2009 with trends since 1995: a systematic analysis. Lancet 2011, 377(9774):1319-1330.
- [34]Bahl R, Martines J, Ali N, Bhan MK, Carlo W, Chan KY, Darmstadt GL, Hamer DH, Lawn JE, McMillan DD, Mohan P, Paul V, Tsai AC, Victora CG, Weber MW, Zaidi AK, Rudan I: Research priorities to reduce global mortality from newborn infections by 2015. Pediatr Infect Dis J 2009, 28(1 Suppl):S43-S48.
- [35]Bahl R, Martines J, Bhandari N, Biloglav Z, Edmond K, Iyengar S, Kramer M, Lawn JE, Manandhar DS, Mori R, Rasmussen KM, Sachdev HP, Singhal N, Tomlinson M, Victora C, Williams AF, Chan KY, Rudan I: Setting research priorities to reduce global mortality from preterm birth and low birth weight by 2015. J Glob Health 2012, 2(1):10403.
- [36]Fontaine O, Kosek M, Bhatnagar S, Boschi-Pinto C, Chan KY, Duggan C, Martinez H, Ribeiro H, Rollins NC, Salam MA, Santosham M, Snyder JD, Tsai AC, Vargas B, Rudan I: Setting research priorities to reduce global mortality from childhood diarrhoea by 2015. PLoS Med 2009, 6(3):e41.
- [37]Lawn JE, Bahl R, Bergstrom S, Bhutta ZA, Darmstadt GL, Ellis M, English M, Kurinczuk JJ, Lee AC, Merialdi M, Mohamed M, Osrin D, Pattinson R, Paul V, Ramji S, Saugstad OD, Sibley L, Singhal N, Wall SN, Woods D, Wyatt J, Chan KY, Rudan I: Setting research priorities to reduce almost one million deaths from birth asphyxia by 2015. PLoS Med 2011, 8(1):e1000389.
- [38]Rudan I, El Arifeen S, Bhutta ZA, Black RE, Brooks A, Chan KY, Chopra M, Duke T, Marsh D, Pio A, Simoes EA, Tamburlini G, Theodoratou E, Weber MW, Whitney CG, Campbell H, Qazi SA, WHO/CHNRI Expert Group on Childhood Pneumonia: Setting research priorities to reduce global mortality from childhood pneumonia by 2015. PLoS Med 2011, 8(9):e1001099.
- [39]Rudan I, Gibson J, Kapiriri L, Lansang MA, Hyder AA, Lawn J, Darmstadt GL, Cousens S, Bhutta ZA, Brown KH, Hess SY, Black M, Gardner JM, Webster J, Carneiro I, Chandramohan D, Kosek M, Lanata CF, Tomlinson M, Chopra M, Ameratunga S, Campbell H, El Arifeen S, Black RE, Child Health and Nutrition Research Initiative (CHNRI): Setting priorities in global child health research investments: assessment of principles and practice. Croat Med J 2007, 48(5):595-604.
- [40]Rudan I, Gibson JL, Ameratunga S, El Arifeen S, Bhutta ZA, Black M, Black RE, Brown KH, Campbell H, Carneiro I, Chan KY, Chandramohan D, Chopra M, Cousens S, Darmstadt GL, Meeks Gardner J, Hess SY, Hyder AA, Kapiriri L, Kosek M, Lanata CF, Lansang MA, Lawn J, Tomlinson M, Tsai AC, Webster J, Child Health and Nutrition Research Initiative: Setting priorities in global child health research investments: guidelines for implementation of CHNRI method. Croat Med J 2008, 49(6):720-733.
- [41]Rudan I, Kapiriri L, Tomlinson M, Balliet M, Cohen B, Chopra M: Evidence-based priority setting for health care and research: tools to support policy in maternal, neonatal, and child health in Africa. PLoS Med 2010, 7(7):e1000308.
- [42]Tomlinson M, Chopra M, Sanders D, Bradshaw D, Hendricks M, Greenfield D, Black RE, El Arifeen S, Rudan I: Setting priorities in child health research investments for South Africa. PLoS Med 2007, 4(8):e259.
- [43]Tomlinson M, Rudan I, Saxena S, Swartz L, Tsai AC, Patel V: Setting priorities for global mental health research. Bull World Health Organ 2009, 87(6):438-446.
- [44]Tomlinson M, Swartz L, Officer A, Chan KY, Rudan I, Saxena S: Research priorities for health of people with disabilities: an expert opinion exercise. Lancet 2009, 374(9704):1857-1862.
- [45]Brown KH, Hess SY, Boy E, Gibson RS, Horton S, Osendarp SJ, Sempertegui F, Shrimpton R, Rudan I: Setting priorities for zinc-related health research to reduce children’s disease burden worldwide: an application of the Child Health and Nutrition Research Initiative’s research priority-setting method. Public Health Nutr 2009, 12(3):389-396.
- [46]Kapiriri L, Tomlinson M, Chopra M, El Arifeen S, Black RE, Rudan I, Child Health and Nutrition Research Initiative (CHNRI): Setting priorities in global child health research investments: addressing values of stakeholders. Croat Med J 2007, 48(5):618-627.
- [47]Lawn JE, Rudan I, Rubens C: Four million newborn deaths: is the global research agenda evidence-based? Early Hum Dev 2008, 84(12):809-814.
- [48]Inter-Agency Working Group on Reproductive Health in CrisesAvailable from: http://www.iawg.net/ webcite
- [49]Inter-Agency Working Group on Reproductive Health in Crises: Neonatal Health: Identifying Priority Questions and Gaps:Thirteenth Annual Meeting of the Inter-agency Working Group (IAWG) on Reproductive Health in Crises Istanbul, Turkey, 14–16 November 2011. 2011. Available from: http://www.iawg.net/2011/ webcite
- [50]Centers for Disease Control and Prevention: The Public Health Approach to Violence Prevention: The Public Health Model. [cited 2013 May 29]; Available from: http://www.cdc.gov/violenceprevention/overview/publichealthapproach.html webcite
- [51]World Health Organization: Every Newborn: an Action Plan to end Preventable Deaths. [Cited 2014 April 15]; Available from: http://www.who.int/maternal_child_adolescent/topics/newborn/enap_consultation/en/ webcite