Determinants of arterial stiffness progression in a Han-Chinese population in Taiwan: a 4-year longitudinal follow-up

BMC Cardiovascular Disorders

Suh-Hang H. Juo¹  Chung Y. Hsu³  Reuy-Tay Lin⁴  Yu-Shan Lee²  Hsiu-Fen Lin⁴  Yi-Chu Liao⁵  Lien-Ying Lin² 

[1] Department of Medical Genetics, College of Medicine, Kaohsiung Medical University, No.100, Shih-Chuan 1st Road, Kaohsiung 807, Taiwan, ROC;Department of Neurology, Neurological Institute, Taichung Veterans General Hospital, 1650 Taiwan Boulevard Sect. 4, Taichung 407, Taiwan, ROC;Department of Neurology, China Medical University Hospital, 2 Yude Road, Taichung 404, Taiwan, ROC;Department of Neurology, College of Medicine, Kaohsiung Medical University, No.100, Shih-Chuan 1st Road, Kaohsiung 807, Taiwan, ROC;Department of Neurology, School of Medicine, National Yang-Ming University, No.155, Sec.2, Linong Street, Taipei 112, Taiwan, ROC

关键词: Obesity;    Blood pressure;    Progression rate;    Pulse wave velocity;    Arterial stiffness;   

Others  :  1225809
DOI  :  10.1186/s12872-015-0093-2

 received in 2015-04-25, accepted in 2015-09-12,  发布年份 2015

【 摘 要 】

Background

Arterial stiffness predicts the future risk of macro- and micro-vascular diseases. Only a few studies have reported longitudinal changes. The present study aimed to investigate the progression rate of arterial stiffness and the factors influencing stiffness progression in a Han Chinese population residing in Taiwan.

Methods

The pulse wave velocity (PWV), elasticity modulus (Ep) and arterial stiffness index (β) of the common carotid artery were measured in 577 stroke- and myocardial infarction-free subjects at baseline and after an average interval of 4.2 ± 0.8 years. Stepwise multivariate linear regression was conducted to elucidate the predictors of stiffness progression.

Results

For both baseline and follow-up data, men had significantly higher values of PWV, Ep and β in comparison to women. The progression rates of PWV, Ep and β were faster in men, but the difference was not statistically significant (ΔPWV = 0.20 ± 0.20 and 0.18 ± 0.20 m/s/yr; ΔEp = 8.17 ± 8.65 and 6.98 ± 8.26 kPa/yr; Δβ = 0.70 ± 0.64 and 0.67 ± 0.56 for men and women, respectively). In the multivariate regression analyses, age, baseline stiffness parameters, baseline mean arterial pressure (MAP), baseline body mass index (BMI) and changes in MAP (ΔMAP) were independent predictors of PWV and Ep progression. There was an inverse correlation between the stiffness parameters at baseline and their progression rate (correlation coefficient (r) = −0.12 to −0.33, p = 0.032–1.6 × 10 ⁻¹⁶ ). Changes in MAP (ΔMAP) rather than baseline MAP were more strongly associated with PWV progression (p = 8.5 × 10 ⁻²⁴and 1.9 × 10 ⁻⁵for ΔMAP and baseline MAP, respectively). Sex-specific analyses disclosed that baseline BMI and changes in BMI (ΔBMI) were significantly associated with stiffness progression in men (p = 0.010–0.026), but not in women.

Conclusions

Aging and elevated blood pressure at baseline and during follow-up were the major determinants of stiffness progression in the Han Chinese population. For men, increased baseline BMI and changes in BMI were additional risk factors.

【 授权许可】

   
2015 Lin et al.

【 图 表 】

Fig. 1.

Fig. 2.

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