Recreational drug use and risks of HIV and sexually transmitted infections among Chinese men who have sex with men: Mediation through multiple sexual partnerships

BMC Infectious Diseases

Han-Zhu Qian⁵  Hong Shang⁷  Sten H Vermund⁵  Wen-Qing Geng⁷  Yong-Jun Jiang⁷  Ming-Hua Zhuang²  Hong-Jing Yan¹  Xi Chen³  Ji-Hua Fu⁶  Zhe Wang⁸  Lin Lu⁴  Yong-Ze Li⁷  Jing Zhang⁷  Zhen-Xing Chu⁷  Qing-Hai Hu⁷  Chen Zhang⁵  Jun-Jie Xu⁷ 

[1] Jiangsu Provincial CDC, Nanjing, China;Shanghai Municipal CDC, Shanghai, China;Hunan Provincial CDC, Changsha, China;Yunnan Provincial Centers for Disease Control and Prevention (CDC), Kunming, China;Vanderbilt Institute for Global Health and Departments of Pediatrics and Medicine, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 750, Nashville 37203, TN, USA;Shandong Provincial CDC, Jinan, China;Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China;Henan Provincial CDC, Zhengzhou, China

关键词: China;    Substance use;    Recreational drug use;    HSV-2;    Syphilis;    HIV;    Unprotected sex;    Multiple sexual partners;    Men who have sex with men;   

Others  :  1118289
DOI  :  10.1186/s12879-014-0642-9

 received in 2014-07-24, accepted in 2014-11-19,  发布年份 2014

【 摘 要 】

Background

Recreational drug use (RDU) may result in sexual disinhibition and higher risk for HIV and other sexually transmitted infections (STIs) among men who have sex with men (MSM) in China. We assessed whether RDU was associated with HIV, syphilis, and herpes simplex virus type 2 (HSV-2) within the context of multiple sexual partnerships and unprotected sex.

Methods

We conducted a cross-sectional study among sexually-active MSM in six Chinese cities (Kunming, Jinan, Changsha, Zhengzhou, Nanjing, and Shanghai) in 2012–2013. We interviewed participants regarding RDU and sexual activity and drew blood for HIV, syphilis, and HSV-2. We fit multiple logistic regression models to assess associations of drug use and HIV, syphilis and HSV-2 infections, controlling for number of sexual partners and unprotected sex.

Results

Of 3830 participants, 28% reported ever using ≥1 of these drugs in the past 6 months: popper (alkyl nitrites), ecstasy, ice (methamphetamine), amphetamine, tramadol, and ketamine. In the past six months, 62% of MSM reported ≥2 sexual partners and 76% did not use condoms at last sexual encounter. HIV, syphilis and HSV-2 prevalences were 9.2%, 12.2%, and 10.3%, respectively.RDU was associated with HIV infection (aOR = 1.67; 95% CI, 1.31-2.13). Men with RDU were more likely to report multiple sexual partners (OR = 1.69; 95% CI, 1.44-1.98) and unprotected sex (aOR = 1.25; 95% CI, 1.05-1.49). The RDU-HIV association persisted (aOR = 1.58; 95% CI = 1.23-2.02) after adjusting for numbers of partners.

Conclusions

RDU was associated with multiple sexual partnerships, unprotected sex, and HIV among Chinese MSM. It is plausible that RDU is a driver of increased sexual/HIV risk and/or may be an associated behavior with sexually risky lifestyles. Community engagement is needed.

【 授权许可】

   
2014 Xu et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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