An unusual case of glomerulonephritis in a patient with non-Hodgkin Mucosal Associated Lymphoid Tissue (MALT) B-cell lymphoma

BMC Nephrology

Adrian Liew¹  Hwei Yee Lee²  Khoon Leong Chuah²  See Cheng Yeo¹ 

[1] Department of Renal Medicine, Tan Tock Seng Hospital, Singapore, Singapore;Department of Pathology, Tan Tock Seng Hospital, Singapore, Singapore

关键词: Renal failure;    Paraneoplastic;    Lupus-like nephritis;    Non-Hodgkin lymphoma;   

Others  :  1082881
DOI  :  10.1186/1471-2369-14-158

 received in 2012-12-09, accepted in 2013-07-18,  发布年份 2013

【 摘 要 】

Background

Kidney involvement in non-Hodgkin lymphoma is well recognized and glomerulonephritis, when present, has been commonly reported to be associated with a membranoproliferative pattern.

Case presentation

We report a case of a 58-year-old lady with a recurrence of non-Hodgkin MALT B-cell lymphoma, presenting with acute kidney injury, nephrotic range proteinuria and a cellular urinalysis. She underwent a renal biopsy that showed a severe diffuse proliferative and exudative lupus-like glomerulonephritis, which is likely paraneoplastic in nature. We discuss the differential diagnosis and possible pathogenesis of glomerular injury in lymphoma-related proliferative glomerulonephritis.

Conclusion

Differentiating between true lupus nephritis and a paraneoplastic glomerulonephritis is important, as it would have significant implications on treatment and clinical course.

【 授权许可】

   
2013 Yeo et al.; licensee BioMed Central Ltd.

【 图 表 】

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