BMC Pulmonary Medicine | |
YKL-40 is correlated with FEV1 and the asthma control test (ACT) in asthmatic patients: influence of treatment | |
Bin Wu1  Dongming Li1  Dong Wu1  Yingying Lǚ1  Zaichun Deng2  Min Chen1  Tianwen Lai1  | |
[1]Department of Respiratory and Critical Care Medicine, Institute of Respiratory Diseases, Affiliated Hospital, Guangdong Medicine College, Zhanjiang 524000, China | |
[2]Department of Respiratory Medicine, Affiliated Hospital of School of Medicine, Ningbo University, Ningbo 315020, China | |
关键词: YKL-40; Exacerbation; CHI3L1; Asthma; | |
Others : 1128540 DOI : 10.1186/1471-2466-15-1 |
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received in 2013-11-28, accepted in 2015-01-06, 发布年份 2015 | |
【 摘 要 】
Background
YKL-40 is also called chitinase-3-like-1 (CHI3L1) protein and may be a marker for asthma. The aims of the present study were to investigate whether serum YKL-40 levels are stable or decreased in patients with asthma after appropriate treatment and to evaluate the correlation of YKL-40 levels with lung function and asthma control test (ACT) results.
Methods
A total of 103 asthmatic patients (mean age 33.1 ± 0.9 years) with diagnosed asthma were enrolled in our study. All patients underwent a detailed clinical examination and completed the ACT questionnaire, serum YKL-40 measurement, and spirometry before (visit 1) and 8 weeks after initiation of treatment (visit 2).
Results
At the follow-up, the median serum YKL-40 level was significantly decreased compared to the levels at visit 1 (75.2 [55.8-86.8] ng/ml versus 54.5 [46.4-58.4] ng/ml, p < 0.001). The serum YKL-40 level was negatively correlated with %FEV1 (r = -0.37, p < 0.001) and ACT score (r = -0.26, p = 0.007) at visit 1. The change in serum YKL-40 levels between the visits was significantly correlated with changes in FEV1 (r = -0.28, p = 0.006) and ACT score (r = -0.22, p = 0.037). Patients with elevated YKL-40 levels had significantly greater corticosteroid use than patients with lower levels.
Conclusions
YKL-40 was reduced in the serum of asthmatic patients after appropriate treatment, and the levels correlated with improvements in %FEV1 and ACT. High levels of serum YKL-40 may be refractory to current asthma treatments.
Trial registration
【 授权许可】
2015 Lai et al.; licensee BioMed Central.
【 预 览 】
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