Ontogeny of small RNA in the regulation of mammalian brain development

BMC Genomics

Murray J Cairns¹  Darryl W Eyles²  Frederick R Walker³  Elizabeth A Mason⁴  Adam P Carroll³  Belinda J Goldie¹  Sharon L Hollins³ 

[1] Schizophrenia Research Institute, Sydney, NSW, Australia;Queensland Centre for Mental Health Research, Wacol, Qld 4076, Australia;Centre for Translational Neuroscience and Mental Health, Hunter Medical Research Institute, Newcastle, NSW 2305, Australia;Queensland Brain Institute, University of Queensland, Brisbane, Qld 4072, Australia

关键词: Neurogenesis;    mRNA;    MicroRNA;    Interactions;    Cortex;   

Others  :  1140655
DOI  :  10.1186/1471-2164-15-777

 received in 2014-07-30, accepted in 2014-09-04,  发布年份 2014

【 摘 要 】

Background

MicroRNAs (miRNAs) play a pivotal role in coordinating messenger RNA (mRNA) transcription and stability in almost all known biological processes, including the development of the central nervous system. Despite our broad understanding of their involvement, we still have a very sparse understanding of specifically how miRNA contribute to the strict regional and temporal regulation of brain development. Accordingly, in the current study we have examined the contribution of miRNA in the developing rat telencephalon and mesencephalon from just after neural tube closure till birth using a genome-wide microarray strategy.

Results

We identified temporally distinct expression patterns in both the telencephalon and mesencephalon for both miRNAs and their target genes. We demonstrate direct miRNA targeting of several genes involved with the migration, differentiation and maturation of neurons.

Conclusions

Our findings suggest that miRNA have significant implications for the development of neural structure and support important mechanisms that if disrupted, may contribute to or drive neurodevelopmental disorders.

【 授权许可】

   
2014 Hollins et al.; licensee BioMed Central Ltd.

【 图 表 】

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