Vitamin A supplementation and risk of atopy: long-term follow-up of a randomized trial of vitamin A supplementation at six and nine months of age

BMC Pediatrics

Christine Stabell Benn¹  Peter Aaby¹  Helle Brander Eriksen¹  Ida Marie Lisse²  Aliu Balde²  Nicholas Kiraly³ 

[1] Research Center for Vitamins and Vaccines (CVIVA), Bandim Health Project, Statens Serum Institut, 5 Artillerivej, Copenhagen S DK-2300, Denmark;Bandim Health Project, Indepth Network, Apartado 861, Bissau, Guinea-Bissau;Gastro and Food Allergy, Murdoch Childrens Research Institute, Royal Children’s Hospital, Flemington Rd, Parkville VIC 3052, Australia

关键词: Vitamin A supplementation;    Measles vaccine;    Immunization;    Atopy;   

Others  :  1144241
DOI  :  10.1186/1471-2431-13-190

 received in 2013-07-21, accepted in 2013-11-15,  发布年份 2013

【 摘 要 】

Background

The World Health Organization recommends high-dose vitamin A supplementation (VAS) for children above six months of age in low-income countries. VAS has been associated with up-regulation of the Th2 response. We aimed to determine if VAS is associated with atopy in childhood.

Methods

Infants in Guinea-Bissau were randomly allocated VAS or placebo, either at six and nine months of age, or only at nine months of age. At six months of age, children were furthermore randomized to measles vaccine or inactivated polio vaccine. At nine months of age all children received measles vaccine. Children were revisited seven years later and skin prick testing was performed. Atopy was defined as a skin prick reaction ≥3 mm.

Results

40 of 263 children (15%) were atopic. Overall VAS had no significant effect on the risk of atopy (Prevalence Ratio 1.23; 95% CI 0.69-2.18). The Prevalence Ratio was 1.60 (0.66-3.90) for males and 1.00 (0.46-2.15) for females.

Conclusions

There was no significant effect of VAS in infancy on atopy later in childhood. The role of infant VAS in the development of atopy is still unclear.

【 授权许可】

   
2013 Kiraly et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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