Factors associated with willingness to participate in clinical trials: a nationwide survey study

BMC Public Health

Geu Lee Park⁴  Seok Hee Jeong¹  Eun Jung Kim²  Sang Hui Chu³ 

[1] College of Nursing, Research Institute of Nursing Science, Chonbuk National University, 567 Baekje-daero, deokjin-gu, Jeonju-si 561-756, Jeollabuk-do, Republic of Korea;Division of Nursing, College of Medicine, Hallym University, Chuncheon, Gangwon-do, Republic of Korea;Nursing Policy and Research Institute, Biobehavioral Research Center, College of Nursing, Yonsei University, Seoul, Republic of Korea;Cardiovascular Center, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea

关键词: Patient participation;    Awareness;    Perception;    Clinical trial;   

Others  :  1090878
DOI  :  10.1186/s12889-014-1339-0

 received in 2014-08-09, accepted in 2014-12-22,  发布年份 2015

【 摘 要 】

Background

This study was conducted to investigate awareness of clinical trials (CTs) including perceptions of favorable feelings about, necessity for, and safety of CTs, the ultimate beneficiary of CTs and the factors associated with willingness to participate in CTs among the general population in South Korea.

Methods

A cross sectional survey study was conducted in a randomly selected national sample of 1,515 Korean.

Results

Perception toward CTs was measured using a scale from 0 (strongly disagree) to 10 (strongly agree). Respondents readily understood the necessity for CTs (M = 7.27, SD = 2.15); had moderately favorable feelings (M = 5.32, SD = 2.31) toward CTs and felt that these CTs were moderately safe (M = 4.71, SD = 1.90). Twenty-five percent of the respondents answered that they would be willing to participate in a CT in the future. Perception of the ultimate benefits of CTs, awareness, favorable feelings, safety, and necessity regarding CTs were identified as significant predictors of willingness to participate in CTs.

Conclusion

An awareness of CTs and the perceptions toward CTs were associated with general public willingness to participate in a CT. Findings from this study can be used in planning outreach and recruitment strategies, and to understand the predictors of CT participation.

【 授权许可】

   
2015 Chu et al.; licensee BioMed Central.

【 参考文献 】

• [1]Karlberg J: Industry sponsored clinical trials in South Korea. Clinical Trial Magnifier 2008, 1(9):179-205.
• [2]Sood A, Prasad K, Chhatwani L, Shinozaki E, Cha SS, Loehrer LL, Wahner-Roedler DL: Patients’ attitudes and preferences about participation and recruitment strategies in clinical trials. Mayo Clin Proc 2009, 84(3):243-7.
• [3]Evelyn B, Toigo T, Banks D, Pohl D, Gray K, Robins B, Ernat J: Participation of racial/ethnic groups in clinical trials and race-related labeling: a review of new molecular entities approved 1995–1999. J Natl Med Assoc 2001, 93(12 Suppl):18S-24.
• [4]Newton SK, Appiah-Poku J: Opinions of researchers based in the UK on recruiting subjects from developing countries into randomized controlled trials. Dev World Bioeth 2007, 7(3):149-56.
• [5]Ross S, Grant A, Counsell C, Gillespie W, Russell I, Prescott R: Barriers to participation in randomised controlled trials: a systematic review. J Clin Epidemiol 1999, 52(12):1143-56.
• [6]Comis RL, Miller JD, Aldige CR, Krebs L, Stoval E: Public attitudes toward participation in cancer clinical trials. J Clin Oncol 2003, 21(5):830-5.
• [7]Janet Yang Z, McComas K, Gay G, Leonard JP, Dannenberg AJ, Dillon H: From information processing to behavioral intentions: exploring cancer patients’ motivations for clinical trial enrollment. Patient Educ Couns 2010, 79(2):231-8.
• [8]Brown DR, Topcu M: Willingness to participate in clinical treatment research among older African Americans and Whites. Gerontologist 2003, 43(1):62-72.
• [9]Shavers VL, Lynch CF, Burmeister LF: Factors that influence African-Americans’ willingness to participate in medical research studies. Cancer 2001, 91(1 Suppl):233-6.
• [10]Wallington SF, Luta G, Noone A, Caicedo L, Lopez-Class M, Sheppard V, et al.: Assessing the awareness of and willingness to participate in cancer clinical trials among immigrant Latinos. J Community Health 2012, 37(2):335-43.
• [11]Kim JW, Kim SJ, Chung YH, Kwon JH, Lee HJ, Chung YJ, Kim YJ, Oh DY, Lee SH, Kim DW, et al.: Cancer patients’ awareness of clinical trials, perceptions on the benefit and willingness to participate: Korean perspectives. Br J Cancer 2008, 99(10):1593-9.
• [12]Hussain-Gambles M, Atkin K, Leese B: South Asian participation in clinical trials: the views of lay people and health professionals. Health Policy 2006, 77(2):149-65.
• [13]Kravitz RL, Paterniti DA, Hay MC, Subramanian S, Dean DE, Weisner T, Vohra S, Duan N: Marketing therapeutic precision: Potential facilitators and barriers to adoption of n-of-1 trials. Contemp Clin Trials 2009, 30(5):436-45.
• [14]Shaya FT, Gbarayor CM, Huiwen Keri Y, Agyeman-Duah M, Saunders E: A perspective on African American participation in clinical trials. Contemp Clin Trials 2007, 28(2):213-7.
• [15]Shavers VL, Lynch CF, Burmeister LF: Knowledge of the Tuskegee study and its impact on the willingness to participate in medical research studies. J Natl Med Assoc 2000, 92(12):563-72.
• [16]Ohmann C, Deimling A: Attitude towards clinical trials: results of a survey of persons interested in research. Inflamm Res 2004, 53(Suppl 2):S142-7.
• [17]Kemp N, Skinner E, Toms J: Randomized clinical trials of cancer treatment–a public opinion survey. Clin Oncol 1984, 10(2):155-61.
• [18]Ellis PM: Attitudes towards and participation in randomised clinical trials in oncology: a review of the literature. Ann Oncol 2000, 11(8):939-45.
• [19]Canvin K, Jacoby A: Duty, desire or indifference? A qualitative study of patient decisions about recruitment to an epilepsy treatment trial. Trials 2006, 7:32. BioMed Central Full Text
• [20]Umutyan A, Chiechi C, Beckett LA, Paterniti DA, Turrell C, Gandara DR, Davis SW, Wun T, Chen MS Jr, Lara PN Jr: Overcoming barriers to cancer clinical trial accrual: impact of a mass media campaign. Cancer 2008, 112(1):212-9.
• [21]Du W, Mood D, Gadgeel S, Simon MS: An educational video to increase clinical trials enrollment among lung cancer patients. J Thorac Oncol 2008, 3(1):23-9.