Effect of low birth weight on childhood asthma: a meta-analysis

BMC Pediatrics

Zhi-Min Chen²  Lan-Fang Tang²  Jin-Ling Liu²  Yuan-Jian Sheng²  Ying-Jun Li¹  Xue-Feng Xu² 

[1] Department of Epidemiology and Health Statistics, School of Public Health, Zhejiang University, Hangzhou, China;Department of Pulmonology, The Children’s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China

关键词: Systematic review;    Meta-analysis;    Childhood asthma;    Birth weight;   

Others  :  1118903
DOI  :  10.1186/1471-2431-14-275

 received in 2014-03-12, accepted in 2014-10-09,  发布年份 2014

【 摘 要 】

Background

Low birth weight is strongly correlated with an increased risk of adult diseases. Additionally, low birth weight might be a risk factor for asthma later in life.

Methods

A systematic literature search of the PubMed database from 1966 to November 2013 was conducted. The criteria for inclusion of papers were as follows: case–control or cohort studies; the odds ratio (OR) or risk ratio (RR) estimates with the corresponding 95% confidence intervals (CIs) were presented, or there were sufficient data for calculation; and studies were published in English up to October 2013. Random-effect and fixed-effect meta-analyses, meta-regression, and cumulative meta-analysis were conducted.

Results

Thirteen cohort studies and 1,105,703 subjects were included. The overall pooled RRs (95% CIs) of asthma risk for low birth weight were 1.162 (fixed-effects model, 95% CI, 1.128–1.197) and 1.152 (random-effects model, 95% CI, 1.082–1.222). In stratified analyses, the effect of low birth weight on childhood asthma was strong, particularly in studies conducted in Europe, those with a small sample size, and those published recently. A meta-regression analysis did not find significant determinants.

Conclusions

This meta-analysis shows that low birth weight significantly increases the risk of childhood asthma.

【 授权许可】

   
2014 Xu et al.; licensee BioMed Central Ltd.

【 图 表 】

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