Body mass index at 11 years and bone mass at age 18: path analysis within the 1993 Pelotas (Brazil) birth cohort study

BMC Musculoskeletal Disorders

Fernando C Barros²  Helen Gonçalves²  Pedro Curi Hallal²  Laura D Howe¹  Fernando Cesar Wehrmeister²  Jeovany Martínez-Mesa²  Maria Cecília Formoso Assunção²  Ana Maria Baptista Menezes²  Ludmila Correa Muniz² 

[1] MRC Integrative Epidemiology Unit at the University of Bristol, School of Social and Community Medicine, University of Bristol, Bristol, UK;Post-Graduate Program in Epidemiology, Federal University of Pelotas, Rua: Marechal Deodoro 1160 (3° andar). CEP, Pelotas 96020-220, Rio Grande do Sul, Brasil

关键词: Adolescence;    Cohort studies;    DXA;    Body composition;    Bone mass;   

Others  :  1161059
DOI  :  10.1186/s12891-015-0529-y

 received in 2014-10-30, accepted in 2015-03-13,  发布年份 2015

【 摘 要 】

Background

We investigated whether Body Mass Index (BMI) at 11 years old has a direct effect on bone mass at age 18 operating through alterations to bone growth and development, or whether the association is mediated by concurrent BMI, fat mass (FM), and fat free mass (FFM).

Methods

Path analysis was used to explore the association between BMI at age 11 and whole-body bone mineral content (BMC) and bone mineral density (BMD) assessed by dual-energy x-ray absorptiometry (DXA) at age 18 in a prospective birth cohort study comprising 3,307 adolescents; we also evaluated the degree to which this association was mediated by BMI, FM (kg) and FFM (kg) assessed by plethysmography (BOD POD) at age 18.

Results

We found a positive association between BMI at age 11 and BMC (males [β = 179.7 g, 95% CI 161.4; 198.0]; females [β = 179.9 g, 95% CI 165.3; 194.6]) and BMD (males [β = 0.030 g/cm2, 95% CI 0.024; 0.035]; females [β = 0.029 g/cm2, 95% CI 0.025; 0.033]) at age 18. This association was largely mediated by BMI and FFM at age 18 in both female and male adolescents. FM at age 18 was not an important mediator.

Conclusions

Concurrent BMI and FFM were the main mediators of the association between BMC/BMD in late adolescence and BMI in early adolescence.

【 授权许可】

   
2015 Muniz et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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