The collateral circulation of the heart

BMC Medicine

Christian Seiler²  Bertram Pitt⁴  Adam Timmis¹  Alexandra J Lansky⁵  Stephan H Schirmer³  Pascal Meier⁵ 

[1] NIHR Biomedical Research Unit, Barts and the London School of Medicine and Dentistry, London Chest Hospital, London, UK;Department of Cardiology, University Hospital Bern, Bern, Switzerland;Department of Cardiology, University Hospital Saarland, Saarland, Germany;Division of Cardiology, University of Michigan Medical Center, Ann Arbor, MI, USA;Division of Cardiology, Yale Medical School, New Haven, CT, USA

关键词: Coronary collateral circulation;    Coronary artery disease;    Arteriogenesis;    Angiogenesis;   

Others  :  857002
DOI  :  10.1186/1741-7015-11-143

 received in 2013-02-22, accepted in 2013-05-17,  发布年份 2013

【 摘 要 】

The coronary arteries have been regarded as end arteries for decades. However, there are functionally relevant anastomotic vessels, known as collateral arteries, which interconnect epicardial coronary arteries. These vessels provide an alternative source of blood supply to the myocardium in cases of occlusive coronary artery disease. The relevance of these collateral arteries is a matter of ongoing debate, but increasing evidence indicates a relevant protective role in patients with coronary artery disease. The collateral circulation can be assessed by different methods; the gold standard involves intracoronary pressure measurements. While the first clinical trials to therapeutically induce growth of collateral arteries have been unavailing, recent pilot studies using external counterpulsation or growth factors such as granulocyte colony stimulating factor (G-CSF) have shown promising results.

【 授权许可】

   
2013 Meier et al.; licensee BioMed Central Ltd.

【 图 表 】

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