Neurobehaviour between birth and 40 weeks’ gestation in infants born <30 weeks’ gestation and parental psychological wellbeing: predictors of brain development and child outcomes

BMC Pediatrics

Peter J Anderson⁴  Lex W Doyle⁴  Fiona Judd¹  Abbey Eeles³  Marc Seal⁵  Angela T Morgan⁶  Leesa G Allinson²  Joy Olsen⁴  Carmen C Pace⁷  Katherine J Lee⁵  Jeanie LY Cheong⁴  Karli Treyvaud⁵  Nisha C Brown³  Deanne K Thompson⁵  Alicia J Spittle¹ 

[1] Neonatal Services, Royal Women's Hospital, 7th Floor, Cnr Grattan Street and Flemington Road, Parkville, Victoria 3052, Australia;Department of Physiotherapy, School of Health Sciences, University of Melbourne, Level 7, Building 104, 161 Barry Street, Carlton, Victoria 3053, Australia;Victorian Infant Brain Studies, Murdoch Childrens Research Institute, 4th Floor, Flemington Road, Parkville, Victoria 3052, Australia;Department of Obstetrics and Gynaecology, 7th Floor, Cnr Grattan Street and Flemington Road, Parkville, Victoria 3052, Australia;Department of Paediatrics, University of Melbourne, Flemington Road, Parkville, Victoria 3052, Australia;Language and Literacy Group, Murdoch Childrens Research Institute, 5th Floor, Flemington Road, Parkville, Victoria 3052, Australia;Melbourne School of Psychological Sciences, University of Melbourne, 12th Floor, Redmond Barry Building, Parkville, Victoria 3010, Australia

关键词: Parent–child interaction;    Parent mental health;    Neurodevelopment;    Magnetic resonance imaging;    Neurobehaviour;    Preterm;   

Others  :  1138883
DOI  :  10.1186/1471-2431-14-111

 received in 2014-04-02, accepted in 2014-04-15,  发布年份 2014

【 摘 要 】

Background

Infants born <30 weeks’ gestation are at increased risk of long term neurodevelopmental problems compared with term born peers. The predictive value of neurobehavioural examinations at term equivalent age in very preterm infants has been reported for subsequent impairment. Yet there is little knowledge surrounding earlier neurobehavioural development in preterm infants prior to term equivalent age, and how it relates to perinatal factors, cerebral structure, and later developmental outcomes. In addition, maternal psychological wellbeing has been associated with child development. Given the high rate of psychological distress reported by parents of preterm children, it is vital we understand maternal and paternal wellbeing in the early weeks and months after preterm birth and how this influences the parent–child relationship and children’s outcomes. Therefore this study aims to examine how 1) early neurobehaviour and 2) parental mental health relate to developmental outcomes for infants born preterm compared with infants born at term.

Methods/Design

This prospective cohort study will describe the neurobehaviour of 150 infants born at <30 weeks’ gestational age from birth to term equivalent age, and explore how early neurobehavioural deficits relate to brain growth or injury determined by magnetic resonance imaging, perinatal factors, parental mental health and later developmental outcomes measured using standardised assessment tools at term, one and two years’ corrected age. A control group of 150 healthy term-born infants will also be recruited for comparison of outcomes. To examine the effects of parental mental health on developmental outcomes, both parents of preterm and term-born infants will complete standardised questionnaires related to symptoms of anxiety, depression and post-traumatic stress at regular intervals from the first week of their child’s birth until their child’s second birthday. The parent–child relationship will be assessed at one and two years’ corrected age.

Discussion

Detailing the trajectory of infant neurobehaviour and parental psychological distress following very preterm birth is important not only to identify infants most at risk, further understand the parental experience and highlight potential times for intervention for the infant and/or parent, but also to gain insight into the effect this has on parent–child interaction and child development.

【 授权许可】

   
2014 Spittle et al.; licensee BioMed Central Ltd.

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