Correlations of gene expression with ratings of inattention and hyperactivity/impulsivity in tourette syndrome: a pilot study

BMC Medical Genomics

Frank R Sharp³  Julie B Schweitzer²  Pieter J Hoekstra¹  Netty GP Bos-Veneman¹  Blythe A Corbett²  Joan R Gunther³  Glen C Jickling³  Bradley P Ander³  Boryana Stamova³  Yingfang Tian⁴ 

[1] Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands;MIND Institute and Department of Psychiatry, University of California at Davis, Sacramento, CA, USA;MIND Institute and Department of Neurology, University of California at Davis, 2805 50th St., Room 2434, Sacramento, CA, 95817, USA;Laboratory of Gene Therapy, College of Life sciences, Shaanxi Normal University, Xi'an, Shaanxi, China

关键词: Tourette syndrome;    Microarray;    Genomics;    RNA expression;    Blood;    Attention-deficit hyperactivity disorder (ADHD);   

Others  :  1134561
DOI  :  10.1186/1755-8794-5-49

 received in 2012-05-05, accepted in 2012-10-09,  发布年份 2012

【 摘 要 】

Background

Inattentiveness, impulsivity and hyperactivity are the primary behaviors associated with attention-deficit hyperactivity disorder (ADHD). Previous studies showed that peripheral blood gene expression signatures can mirror central nervous system disease. Tourette syndrome (TS) is associated with inattention (IA) and hyperactivity/impulsivity (HI) symptoms over 50% of the time. This study determined if gene expression in blood correlated significantly with IA and/or HI rating scale scores in participants with TS.

Methods

RNA was isolated from the blood of 21 participants with TS, and gene expression measured on Affymetrix human U133 Plus 2.0 arrays. To identify the genes that correlated with Conners’ Parents Ratings of IA and HI ratings of symptoms, an analysis of covariance (ANCOVA) was performed, controlling for age, gender and batch.

Results

There were 1201 gene probesets that correlated with IA scales, 1625 that correlated with HI scales, and 262 that correlated with both IA and HI scale scores (P<0.05, |Partial correlation (r_p)|>0.4). Immune, catecholamine and other neurotransmitter pathways were associated with IA and HI behaviors. A number of the identified genes (n=27) have previously been reported in ADHD genetic studies. Many more genes correlated with either IA or HI scales alone compared to those that correlated with both IA and HI scales.

Conclusions

These findings support the concept that the pathophysiology of ADHD and/or its subtypes in TS may involve the interaction of multiple genes. These preliminary data also suggest gene expression may be useful for studying IA and HI symptoms that relate to ADHD in TS and perhaps non-TS participants. These results will need to be confirmed in future studies.

【 授权许可】

   
2012 Tian et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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