Profiles of responses of immunological factors to different subtypes of Kawasaki disease

BMC Musculoskeletal Disorders

Lei Zhao¹  Shu-Ling Zhang¹  Kun Xia³  Rui-Geng Wang³  Fan Liu³  Jie Liu²  Wei Yin³  Li-Juan Xiong¹  Gang Li⁴  Yan Ding³ 

[1] Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P.R. China;Department of Critical-Care Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, P.R. China;Department of Rheumatology and Immunology, Medical and Health Center for Women and Children, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, P.R. China;Department of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, P.R. China

关键词: Coronary artery lesion;    Immunoglobulin;    B lymphocytes;    Natural killer cells;    T lymphocyte subsets;    Mucocutaneous lymph node syndrome;    Kawasaki disease;   

Others  :  1232764
DOI  :  10.1186/s12891-015-0744-6

 received in 2015-07-01, accepted in 2015-10-01,  发布年份 2015

【 摘 要 】

Background

The responses of immunological factors to different subtypes of Kawasaki disease (KD) remain poorly understood.

Methods

We recruited 388 patients with KD, 160 patients with infectious febrile disease and 85 normal children who served as control subjects. Both the levels and percentages of T lymphocyte subsets, natural killer cells (NK cells) and B cells were analyzed via flow cytometry. The levels of serum IgG, IgM, IgA and C3, C4 were assessed via velocity scatter turbidimetry.

Results

The most significant differences noted between the patients with infectious febrile disease and the normal children were the elevated levels of B cells, C3 and the ratio of CD4/CD8, and the decreased levels of CD8+ T cells and NK cells, as well as the moderate increase in the absolute value of the CD3+ cells. The decreased T cell levels and the elevated B cell levels were helpful in distinguishing typical KD from atypical KD; the elevated T cell levels, the elevated NK cell and B cell levels and the decreased B cell levels were helpful in predicting the effectiveness of IVIG; low C3 and C4 levels were linked with prodromal infections.

Conclusions

Lymphocytes subsets and complement markers may be useful in differentiating among the different subtypes of KD and in helping clinicians understand the pathophysiology of KD.

【 授权许可】

   
2015 Ding et al.

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