Determinant and outcome of early diagnosis of HIV infection among HIV-exposed infants in southwest Ethiopia

BMC Research Notes

Misrak Makonnen²  Mikael Gebre-Mariam³  Zinash D Robi³  Gemechis Hundessa³  Marina Trivelli¹  Sibhatu Biadgilign⁴  Gebremedhin Derebe³ 

[1] St. Luke Catholic Hospital and College of Nursing and Midwifey, Wolliso, Ethiopia;IntraHealth International, Addis Ababa, Ethiopia;Ethiopian Catholic Church, Health and HIV/AIDS Department, Addis Ababa, Ethiopia;Independent Public Health Consultant, Addis Ababa, Ethiopia

关键词: Ethiopia;    HIV-exposed infants;    HIV infection;    EID;    Outcome;   

Others  :  1132723
DOI  :  10.1186/1756-0500-7-309

 received in 2014-05-16, accepted in 2014-05-19,  发布年份 2014

【 摘 要 】

Background

Preventing mother-to-child transmission (PMTCT) of human immunodeficiency virus infection (HIV) has been a fundamental advancement in the acquired immunodeficiency syndrome (AIDS) response for the past decade. Several countries have made great strides in the efforts to prevent HIV through mother-to-child transmission. The objective of this study is to assess the determinant and outcome of early diagnosis of HIV infection among HIV-exposed infants in southwest Ethiopia.

Methods

An institutional based retrospective cohort study was conducted in a hospital. Medical records of HIV-exposed infants and their mothers enrolled into the program were reviewed. Data entry and analysis was carried out using SPSS version 20 for Windows.

Results

A total of 426 HIV exposed infant-mother pairs where both mother and infants received a minimum ARV intervention for PMTCT were included in the study. Two hundred fifty-four (59.6%) of mothers had attended antenatal care (ANC). Of all participants, 234(54.9%) mothers did not receive any PMTCT prophylaxis during ANC, while only 104(24.4) received antiretroviral (ART) as PMTCT prophylaxis and 163(38.3%) claimed that did not observe any infant PMTCT interventions while 135(31.7%) of the infants received single-dose NVP + AZT. About 385(90.4%) infants were not infected at their final infection status. Those mothers who did not attended ANC follow-up, infants on mixed and complementary feeding and infants weaned off and mothers who were in WHO clinical stage III and IV were more likely to have HIV sero positive infant.

Conclusion

This study showed that 385(90.4%) of the infants were not infected at their final infection status. Therefore, encouraging pregnant women to visit health facilities during their course of pregnancy, focusing on exclusive breast feeding counseling and promotion, and early initiation of antiretroviral treatment to HIV infected pregnant women are recommend.

【 授权许可】

   
2014 Derebe et al.; licensee BioMed Central Ltd.

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