(18F)Fluoro-deoxy-D-glucose uptake of knee joints in the aspect of age-related osteoarthritis: a case-control study

BMC Musculoskeletal Disorders

Eun Jung Kong²  Young Hoon Hong¹ 

[1] Department of Internal Medicine, Yeungnam University School of Medicine, Daegu, South Korea;Department of Nuclear Medicine, Yeungnam University School of Medicine, Daegu, South Korea

关键词: Osteoarthritis;    Aging;    PET;    F-FDG;   

Others  :  1132738
DOI  :  10.1186/1471-2474-14-141

 received in 2012-11-02, accepted in 2013-04-18,  发布年份 2013

【 摘 要 】

Background

This study investigated ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) uptake at knee joints for determination of metabolic alteration in association with the advance of age and joint degeneration such as osteoarthritis (OA).

Methods

A total of 166 knees from 83 healthy persons who presented for routine health examination and positron emission tomography-computed tomography (PET/CT) were enrolled in this study. History of knee OA and joint symptoms and signs were reviewed. The maximum standardized uptake values (SUVmax) of cartilage and mean SUV (SUVmean) between the epiphyseal plates of femur and tibia were evaluated at knee joints. Assessment of radiological bony changes was performed using the Kallgren-Lawrence (K/L) grading system with reconstructed CT images of the knee. The joint symptoms and signs were counted and used for diagnosis of clinical and radiological OA of the knee.

Results

The SUVmean of the knee joints showed a remarkable increase with aging in females (r = 0.503, p < 0.01). Remarkable changes of SUVmean were observed with history of OA (p < 0.01). The SUVmean of joint and the intra-articular SUVmax showed higher values in clinical and radiological OA than in normal joints (p < 0.01). Joint-SUVmean showed significant correlation with OA severity graded according to K/L score (p < 0.05). The intra-articular SUVmax showed a significant increase in symptomatic joints, indicating OA in correlation with the joint-SUVmean (p = 0.01).

Conclusions

The increasing ¹⁸F-FDG uptakes of knee joints showed agreement with aging in females and clinical and radiological knee OA, indicating that the metabolic alterations were consistent with diagnosis and demographic aspect of OA as a surrogate marker for degeneration of the knee in association with aging.

【 授权许可】

   
2013 Hong and Kong; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

【 参考文献 】

• [1]Felson D: Epidemiology of hip and knee osteoarthritis. Epidemiol Rev 1988, 10:1-28.
• [2]Buckwalter JA, Mankin HJ, Grodzinsky AJ: Articular cartilage and osteoarthritis. Instr Course Lect 2005, 54:465-480.
• [3]Resnick D: Degenerative disease of extraspinal locations. In Diagnosis of bone and joint disorder. 4th edition. Philadelphia: W.B. Saunders; 2002:1271-1381.
• [4]Inerot S, Heinegard D: Articular-cartilage proteoglycans in aging and osteoarthritis. Biochem J 1978, 169:143-156.
• [5]Sugawara Y, Braun DK, Kison PV, Russo JE, Zasadny KR, Wahl RL: Rapiddetection of human infections with fluorine-18 fluorodeoxyglucose and positronemission tomography: preliminary results. Eur J Nucl Med 1998, 25:1238-1243.
• [6]Bakheet SM, Powe J: Fluorine-18-fluorodeoxyglucose uptake in rheumatoidarthritis–associated lung disease in a patient with thyroid cancer. J Nucl Med 1998, 39:234-236.
• [7]Yun M, Kim W, Adam LE, Alnafisi N, Herman C, Alavi A: F-18 FDG uptake in apatient with psoriatic arthritis: imaging correlation with patient symptoms. Clin Nucl Med 2001, 26:692-693.
• [8]Meller J, Koster G, Liersch T, Siefker U, Lehmann K, Meyer I: Chronicbacterial osteomyelitis: prospective comparison of 18F-FDG imaging with a dualheadcoincidence camera and (111)In-labeled autologous leucocyte scintigraphy. Eur J Nucl Med Mol Imag 2002, 29:53-60.
• [9]Johnston JD, McLennan CE, Hunter DJ, Wilson DR: In vivo precision of a depth-specific topographic mapping technique in the CT analysis of osteoarthritic and normal proximal tibial subchondral bone density. Skeletal Radiol 2011, 40:1057-1064.
• [10]Kellgren JH, Lawrence JS: Radiological assessment of osteoarthritis. Ann Rheum Dis 1957, 16:494-502.
• [11]Brown RS, Wahl RL: Overexpression of Glut-1 glucose transporter in humanbreast cancer. An immunohistochemical study. Cancer 1993, 72:2979-2985.
• [12]Wahl RL: Principle and practice of positron emission tomography. Philadelphia: Lippincott Williams & Willkins; 2002.
• [13]Wandler E, Kramer EL, Sherman O, Babb J, Scarola J, Rafii M: Diffuse FDGShoulder Uptake on PET Is Associated with Clinical Findings of Osteoarthritis. Am J Roentgenol 2005, 185:797-803.
• [14]Nakamura H, Masuko K, Yudoh K, Kato T, Nishioka K, Sugihara T: Positronemission tomography with 18F-FDG in osteoarthritic knee. Osteoarthr Cartil 2007, 15:673-681.
• [15]Wluka AE, Cicuttini FM, Spector TD: Menopause, oestrogens and arthritis. Maturitas 2000, 35:183-199.
• [16]Pelletier G, El-Alfy M: Immunocytochemical localization of estrogen receptorsalpha and beta in human reproductive organs. J Clin Endocrinol Metab 2000, 85:4835-4840.
• [17]Richmond RS, Carlson CS, Register TC, Shanker G, Loeser RF: Functionalestrogen receptors in adult articular cartilage: Estrogen replacement therapyincreases chondrocyte synthesis of proteoglycans and insulin-like growth factorbinding protein 2. Arthritis Rheum 2000, 43:2081-2090.
• [18]Mayes PA: Glycolysis & the oxidation of pyruvate. In Harper’s biochemistry. Edited by Murray RK, Granner DK, Mayes PA, Rodwell VW. Norwalk, Connecticut/San Mateo, California: Appleton & Lange; 1988:158-164.
• [19]Pearle AD, Warren RF, Rodeo SA: Basic science of articular cartilage and osteoarthritis. Clin Sports Med 2005, 24:1-12.