Breed, sex and anatomical location-specific gene expression profiling of the porcine skeletal muscles

BMC Genetics

Xuewei Li²  Mingzhou Li²  Jinyong Wang¹  Surong Shuai²  Li Zhu²  Anan Jiang²  Lei Chen¹  Jideng Ma²  Chaowei Zhou²  Jie Zhang² 

[1] Chongqing Academy of Animal Science, Chongqing 402460, China;Institute of Animal Genetics & Breeding, College of Animal Science & Technology, Sichuan Agricultural University, Ya’an, Sichuan 625000, China

关键词: Pig;    Muscle;    Microarray;    Gene expression;   

Others  :  1086953
DOI  :  10.1186/1471-2156-14-53

 received in 2013-03-11, accepted in 2013-06-07,  发布年份 2013

【 摘 要 】

Background

Skeletal muscle is one of the most important economic traits in agricultural animals, especially in pigs. In the modern pig industry, lean type pigs have undergone strong artificial selection for muscle growth, which has led to remarkable phenotypic variations compared with fatty type pigs, making these different breeds an ideal model for comparative studies.

Results

Here, we present comprehensive gene expression profiling for the white (longissimus dorsi muscle) and the red (psoas major muscle) skeletal muscles among male and female fatty Rongchang, feral Tibetan and lean Landrace pigs, using a microarray approach. We identified differentially expressed genes that may be associated the phenotypic differences of porcine muscles among the breeds, between the sexes and the anatomical locations. We also used a clustering method to identify sets of functionally coexpressed genes that are linked to different muscle phenotypes. We showed that, compared with the white muscles, which primarily modulate metabolic processes, the red muscles show a tendency to be a risk factor for inflammation and immune-related disorders.

Conclusions

This analysis presents breed-, sex- and anatomical location-specific gene expression profiles and further identified genes that may be associated with the phenotypic differences in porcine muscles among breeds, between the sexes and the anatomical locations.

【 授权许可】

   
2013 Zhang et al.; licensee BioMed Central Ltd.

【 图 表 】

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