Clinical outcome in patients with acute coronary syndrome and outward remodeling is associated with a predominant inflammatory response

BMC Research Notes

Francisco Blanco-Favela²  María Victoria Legorreta-Haquet²  Mariano Ledesma-Velasco⁴  Arturo Abundes Velazco¹  Silvestre Armando Montoya-Guerrero⁴  Karina Chávez-Rueda²  Gabriela Borrayo-Sánchez⁵  Guillermo Careaga-Reyna³  Luis Chávez-Sánchez²  Alejandra Madrid-Miller⁴ 

[1] Servicio de Hemodinamia, Instituto Nacional de Cardiología, México, DF, México;Unidad de Investigación Médica en Inmunología, Unidad Médica de Alta Especialidad, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Avenida Cuauhtémoc 330, Col. Doctores, CP: 06720 México City, México;Unidad Médica de Alta Especialidad, Hospital General del Centro Médico Nacional la Raza, Instituto Mexicano del Seguro Social, México, DF, México;División de Investigación en Salud y Servicio de Hemodinamia de la Unidad Médica de Alta Especialidad, Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México, DF, México;Coordinación de Investigación en Salud, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México, DF, México

关键词: Inflammation;    Low-density lipoprotein;    Acute coronary syndrome;   

Others  :  1129282
DOI  :  10.1186/1756-0500-7-669

 received in 2014-04-08, accepted in 2014-09-18,  发布年份 2014

【 摘 要 】

Background

Pro-inflammatory molecules and low-density lipoproteins play essential roles in the atherosclerosis. The aim of our study was to establish an association among the cytokines secreted by peripheral blood mononuclear cells and the serum concentration in patients with unstable angina and coronary outward remodeling before and after percutaneous coronary intervention. The clinical and coronary responses were evaluated 6 months after the procedure.

Findings

Twenty-two patients with unstable angina were evaluated prior to after percutaneous coronary intervention and 6 months after procedure by coronary intravascular ultrasound. Eleven of the patients had recurrent angina, while 9 presented restenosis and an increase in the percentage of total plaque area. These 11 patients displayed higher levels of C-reactive protein than those without coronary events (1.27 vs. 0.43 mg/dl, respectively; p = 0.029) and a tendency to increase levels of interleukin (IL)-8 and transforming growth factor-β1, but lower levels of IL-10 (52.09 vs. 141.5 pg/ml, respectively; p = 0.035). Activated peripheral blood mononuclear cells from patients with restenosis presented higher levels of proliferation, CD86 expression and higher IL-1, and increased IL-10 compared to those in patients without restenosis.

Conclusions

Patients with unstable angina and coronary outward remodeling who displayed a pro-inflammatory response experienced recurrent coronary events and an increased percentage of total plaque area. In contrast, better outcomes were observed in patients with anti-inflammatory responses. This response could be secondary to low-density lipoproteins.

【 授权许可】

   
2014 Madrid-Miller et al.; licensee BioMed Central Ltd.

【 图 表 】

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