Yield of close contact tracing using two different programmatic approaches from tuberculosis index cases: a retrospective quasi-experimental study

BMC Pulmonary Medicine

Marcus Barreto Conde³  Fernanda Carvalho Queiroz de Mello¹  Anne Efron²  Michelle Cailleaux–Cezar¹  Carla Loredo¹ 

[1] Institute of Thoracic Diseases of Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland, USA;Hospital Universitário Clementino Fraga Filho, Cidade Universitária, Rua Professor Rodolpho Paulo Rocco n° 255, 6° andar, Rio de Janeiro 21941-913, Brazil

关键词: Latent tuberculosis;    Diagnosis;    Contact;    Tuberculosis;   

Others  :  1109552
DOI  :  10.1186/1471-2466-14-133

 received in 2014-02-20, accepted in 2014-07-17,  发布年份 2014

【 摘 要 】

Background

Being a contact of a pulmonary tuberculosis (TB) case is a risk factor for active and latent TB. The objective of this study is to determine the contact tracing yield using two different programmatic definitions of close contact in the city of Rio de Janeiro, Brazil.

Methods

This is a retrospective quasi-experimental study. Data were obtained by reviewing the medical records from TB index cases and their close contacts admitted to the Outpatient TB Clinic of the Institute of Thoracic Diseases, University of Rio de Janeiro. From January 2001 to December 2004, a close contact was defined as an individual who shared an enclosed space with a TB index case for a total period of ≥ 100 hours, whereas from January 2005 to December 2008 the definition of close contact was changed to an individual who shared an enclosed space with a TB index case ≥ 4 hours a week. The primary outcome of this study was newly diagnosed pulmonary TB cases and the secondary outcome was the prevalence of latent TB infection (LTBI) among close contacts during both periods.

Results

From 2001–2004, 810 close contacts from 257 index cases were evaluated and the prevalence of active TB and LTBI were 2% (16/810) and 62% (496/794), respectively. From 2005–2008, 1,310 close contacts from 369 index cases were identified and the prevalence of active TB and LTBI were 2.7% (35/1,310) and 69% (877/1,275), respectively. There was not a statically significant difference in the detection of active TB (p = 0.3) between the 2 time periods, but the detection of LTBI was significant higher (p = 0.003). The number needed to screen (contacts/new cases) decreased from 50 to 37 and the number need to contact trace (index cases/new cases) decreased from 16 to 10 from 2001–2004 to 2005–2008.

Conclusion

In conclusion, the findings of this study suggest that the less conservative definition of TB close contacts (sharing space ≥ 4 h/week) can be a helpful tool for increasing the rate of diagnosis for newly active pulmonary TB cases and for the detection of LTBI among contacts of active pulmonary TB cases.

【 授权许可】

   
2014 Loredo et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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