Report of depressive symptoms on waiting list and mortality after liver and kidney transplantation: a prospective cohort study

BMC Psychiatry

Bruno Falissard⁴  Bernard Charpentier⁷  Denis Castaing²  Philippe Lang⁵  Didier Samuel⁶  Antoine Durrbach³  Isabelle Varescon¹  Caroline Barry⁸  Emmanuelle Corruble⁹ 

[1] Paris V University, Hepatology and Surgery department of Paul Brousse University Hospital, France;Head of the surgery department of Paul Brousse University Hospital. Assistance Publique-Hopitaux de Paris, France;INSERM U542, Nephrology Department of Bicetre University Hospital, Assistance Publique-Hopitaux de Paris;INSERM U669, Paris XI University, Department of Biostatistics and Public Health, Paul Brousse Hospital, Assistance Publique-Hôpitaux de Paris; 94800 Villejuif, France;Nephrology Department of Creteil University Hospital, Assistance Publique-Hopitaux de Paris, France;Head of the hepatology department of Paul Brousse University Hospital, Assistance Publique-Hopitaux de Paris, France;INSERM U542, Nephrology Department of Bicetre University Hospital, Assistance Publique-Hopitaux de Paris, France;INSERM U 669, Bicetre University Hospital, Assistance Publique-Hopitaux de Paris; 94275 Le Kremlin Bicêtre, France;INSERM U 669, Paris XI University, Psychiatry Department of Bicetre University Hospital, Assistance Publique-Hopitaux de Paris; 94275 Le Kremlin Bicêtre, France

关键词: outcome;    kidney;    liver;    transplantation;    self-assessment;    depressive symptoms;   

Others  :  1124454
DOI  :  10.1186/1471-244X-11-182

 received in 2011-04-12, accepted in 2011-11-21,  发布年份 2011

【 摘 要 】

Background

Little research has explored pre-transplantation psychological factors as predictors of outcome after liver or kidney transplantation. Our objective is to determine whether report of depressive symptoms on waiting list predicts outcome of liver and kidney transplantation.

Methods

Patients on waiting list for liver or kidney transplantation were classified for report or non-report of depressive symptoms on waiting list. 339 were transplanted 6 months later on average, and followed prospectively. The main outcome measures were graft failure and mortality 18 months post-transplantation.

Results

Among the 339 patients, 51.6% reported depressive symptoms on waiting list, 16.5% had a graft failure and 7.4% died post-transplantation.

Report of depressive symptoms on waiting list predicted a 3 to 4-fold decreased risk of graft failure and mortality 18-months post-transplantation, independently from age, gender, current cigarette smoking, anxiety symptoms, main primary diagnosis, UNOS score, number of comorbid diagnoses and history of transplantation. Data were consistent for liver and kidney transplantations. Other baseline predictive factors were: for graft failure, the main primary diagnosis and a shorter length since this diagnosis, and for mortality, older age, male gender and the main primary diagnosis.

Conclusion

Further studies are needed to understand the underlying mechanisms of the association between report of depressive symptoms on waiting list and decreased risk of graft failure and mortality after transplantation.

【 授权许可】

   
2011 Corruble et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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